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. 2012 Jul 11;7(7):e40382. doi: 10.1371/journal.pone.0040382

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Duwal et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: Predicted intracellular pharmacokinetics of TFV-DP in PBMCs after a single 300 mg oral TDF dose. Solid black circle and horizontal error bar indicate the value and its range. B: Trough levels of TFV-DP in PBMCs following 300 mg oral TDF every 24hours, indicating the accumulation of active compound. The solid black circle and the horizontal error bar indicate the time until plateau concentrations are reached and the range for this parameter. Blue cirles, black squares, green diamonds, red downward pointing triangles, magenta upward-pointing triangles, cyan right-ward pointing triangles, black left-pointing triangles and blue asterisks indicate individual predictions for 8 patients.

Inline graphic — A: Predicted intracellular pharmacokinetics of TFV-DP in PBMCs after a single 300 mg oral TDF dose. Solid black circle and horizontal error bar indicate the value and its range. B: Trough levels of TFV-DP in PBMCs following 300 mg oral TDF every 24hours, indicating the accumulation of active compound. The solid black circle and the horizontal error bar indicate the time until plateau concentrations are reached and the range for this parameter. Blue cirles, black squares, green diamonds, red downward pointing triangles, magenta upward-pointing triangles, cyan right-ward pointing triangles, black left-pointing triangles and blue asterisks indicate individual predictions for 8 patients.