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. 2012 Jul 11;7(7):e40382. doi: 10.1371/journal.pone.0040382

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Duwal et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The solid blue-, dash-dotted green, dashed red and dotted black lines show the concentration-response profile for virus inoculum size 1, 5, 20 and 100 respectively. The thick dashed horizontal black line indicates the TFV-DP concentration, which prevents 50% of infections (). The dark grey area indicates the TFV-DP concentration range achieved during once daily 300 mg oral TDF dosing with 100% adherence, whereas the light grey extension to the left indicates the range of concentrations resulting from imperfect adherence. Predictions are based on the approximate analytic solution derived in Text S2.

Inline graphic — The solid blue-, dash-dotted green, dashed red and dotted black lines show the concentration-response profile for virus inoculum size 1, 5, 20 and 100 respectively. The thick dashed horizontal black line indicates the TFV-DP concentration, which prevents 50% of infections (). The dark grey area indicates the TFV-DP concentration range achieved during once daily 300 mg oral TDF dosing with 100% adherence, whereas the light grey extension to the left indicates the range of concentrations resulting from imperfect adherence. Predictions are based on the approximate analytic solution derived in Text S2.