Table 1. Pharmacokinetic and pharmacodynamic parameters.

param.	value	param.	value
	0.12 h		244 L
	0.2926 h		0.006 [0.002;0.026] h
	0.1537 h		1
	75.7 µg. L	F	0.32
	29.3 µg. L		1.44 [0.5;24] µg. L. h

median parameter and range. see Table 4 for individual values. value set to 1 [28]. parameter from [12]. computed using eq. (S2), Text S1.