Table 2:

Changes in spasticity, pain and cognitive performance, by treatment

Performance measure	Placebo		Cannabis		Mean difference		Effect
	Before treatment	After treatment	Before treatment	After treatment	Cannabis	Placebo
Spasticity, modified Ashworth score, mean (95% CI)*	8.92 (8.03 to 9.79)	8.71 (7.57 to 9.71)	9.13 (8.21 to 10.07)	6.18 (5.13 to 7.21)	2.95 (2.49 to 3.38)	0.21 (−0.09 to 0.51)	2.74 (2.20 to 3.14)
Pain, visual analogue score, mean (95% CI)†	14.51 (9.16 to 21.75)	11.52 (7.21 to 18.32)	16.61 (10.79 to 24.93)	8.34 (4.89 to 14.39)	8.27 (4.51 to 13.49)	2.99 (0.04 to 6.55)	5.28 (2.48 to 10.01)
Physical performance, timed walk, s, mean (95% CI)‡	11.68 (8.87 to 16.41)	11.70 (8.81 to 16.98)	11.66 (8.90 to 16.69)	12.89 (9.55 to 17.94)	1.23 (0.33 to 2.63)	0.03 (−0.95 to 1.63)	1.20 (0.15 to 4.31)
Cognitive function, PASAT score, mean (95% CI)§	138.08 (123.76 to 149.74)	138.43 (123.37 to 150.38)	140.78 (127.31 to 151.52)	132.46 (116.38 to 144.07)	8.32 (4.95 to 14.16)	−0.35 (−2.92 to 2.47)	8.67 (4.10 to 14.31)

Note: CI = confidence interval, PASAT = paced auditory serial addition test.

^*Scores range from 0 to 24, with higher scores suggesting greater spasticity.

^†Scores range from 0 to 100, with higher scores suggesting more severe pain.

^‡Times range from 0 to 66 s, with higher scores suggesting a slower pace.

^§Scores range from 0 to 196, with higher scores suggesting better cognitive performance.