Table 1.

(A) Univariate SNP-IC₅₀ Associations with p<10⁻⁵ from Univariate Analysis of the Gemcitabine Study. (B) Nine loci (Regions with More Than One SNP with p<0.0001) associated with IC₅₀

	SNP	Chromosome	Position	Nearest gene	MAF	Correlation	p
(A)	rs4272382	8	8470898	CLDN23	0.132	−0.39	6.1E-07
	rs3775182	4	87198607	MAPK10	0.109	0.38	9.6E-07
	rs2290344	15	53407088	PIGB	0.254	0.36	3.6E-06
	rs10761082	9	106555990	NIPSNAP3A	0.36	0.36	4.9E-06
	rs2472476	9	106571777	NIPSNAP3B	0.389	0.35	8.5E-06
(B)	rs7713001	5	67999371	PIK3R1	0.459	−0.32	4.5E-05
	rs12188464	5	67999705	PIK3R1	0.459	−0.32	4.5E-05
	rs13171512	5	68000787	PIK3R1	0.462	−0.32	3.9E-05
	rs2107331	5	135405248	TGFBI	0.456	−0.34	1.5E-05
	rs2282791	5	135405629	TGFBI	0.477	0.32	4.3E-05
	rs7192	6	32519624	HLA-DRA	0.374	0.31	5.7E-05
	rs3129890	6	32522251	HLA-DRA	0.342	0.34	1.0E-05
	rs2922876	8	6384104	MCPH1; ANGPT2	0.164	−0.31	7.2E-05
	rs1375668	8	6384278	MCPH1; ANGPT2	0.363	−0.31	9.1E-05
	rs4272382	8	8470898	CLDN23	0.132	−0.39	6.1E-07
	rs4595128	8	8471286	CLDN23	0.202	−0.32	3.2E-05
	rs10761082	9	106555990	NIPSNAP3A	0.36	0.36	4.9E-06
	rs2472476	9	106571777	NIPSNAP3B	0.389	0.35	8.5E-06
	rs12244977	10	58762688	LOC100128586	0.19	−0.31	9.4E-05
	rs12256364	10	58765694	LOC100128586	0.19	−0.31	9.4E-05
	rs12050885	15	53345916	RAB27A	0.379	0.33	2.2E-05
	rs11636687	15	53392444	PIGB	0.42	0.32	5.3E-05
	rs2290344	15	53407088	PIGB	0.254	0.36	3.6E-06
	rs12050587	15	53414820	PIGB	0.45	0.32	5.0E-05
	rs8024695	15	53426597	PIGB	0.287	0.34	1.4E-05
	rs11639680	16	5500905	NPM1P3	0.193	0.33	2.8E-05
	rs4511535	16	5506393	NPM1P3	0.199	0.31	6.0E-05

MAF, minor allele frequency; SNP, single-nucleotide polymorphism; IC₅₀, effective dose that kills 50% of cells.