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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Neurochem Int. 2012 Jan 13;61(4):593–600. doi: 10.1016/j.neuint.2011.12.020

Figure 3.

Figure 3

Activity of coumarin derivatives on NMDA receptor responses. After obtaining a steady-state response to 10 μM L-glutamate plus 10 μM glycine, each compound was tested at 100 μM for the inhibition or potentiation of responses by GluN1/GluN2A (2A), GluN1/GluN2B (2B), GluN1/GluN2D (2D) and in some cases GluN1/GluN2C (2C) receptors. At a concentration of 1 μM UBP658 inhibited agonist stimulated responses on GluN1/GluN2A and GluN1/GluN2B by 26.3 ± 5.9 and 2.3 ± 3.5 %, respectively. Values represent mean % inhibition ± s.e.m., n ≥ 4.