Table 3.

Multivariable predictors of hospital length-of-stay ≥3 days among children with severe bronchiolitis associated with respiratory syncytial and/or human rhinovirus (n=1,866)

Characteristics	Odds Ratio (95%CI)	P-value
Age in months
<1 month	2.57 (1.73–3.82)	<0.001
1–1.9	1.75 (1.14–2.69)	0.01
2–3.9	1.21 (0.89–1.66)	0.22
4–5.9	1.37 (0.94–2.00)	0.11
6–11.9	0.99 (0.69–1.43)	0.95
≥12	1.00 (reference)
Female	1.12 (0.91–1.37)	0.30
Race
White	1.00 (reference)
Black	0.79 (0.62–1.01)	0.06
Other or missing	1.07 (0.75–1.53)	0.70
Maternal smoking during pregnancy	1.15 (0.86–1.55)	0.35
Gestational age, weeks
<32	2.57 (1.44–4.57)	0.001
32–36	1.26 (0.94–1.68)	0.12
≥37 or ‘full term’	1.00 (reference)
History of eczema
No	1.00 (reference)
Yes	1.15 (0.83–1.59)	0.41
Missing	0.59 (0.26–1.33)	0.20
History of intubation	0.95 (0.71–1.28)	0.75
Major, relevant comorbid medical disorder	1.14 (0.86–1.49)	0.36
Presence of apnea (chart)	1.14 (0.77–1.71)	0.51
Respiratory rate per minute	1.00 (0.99–1.01)	0.95
Retractions
None	1.00 (reference)
Mild	1.62 (1.23–2.12)	0.001
Moderate or severe	2.05 (1.45–2.91)	<0.001
Missing	1.64 (0.94–2.86)	0.08
Oxygen saturation by pulse ox or ABG
<90	2.06 (1.45–2.93)	<0.001
90–93.9	1.26 (0.98–1.62)	0.07
≥94	1.00 (reference)
Oral intake
Adequate	1.00 (reference)
Inadequate	1.31 (0.93–1.84)	0.12
Missing	1.19 (0.81–1.72)	0.37
ICU	5.33 (3.01–9.44)	<0.001
RSV/HRV status
RSV only infection	1.00 (reference)
HRV only infection	0.36 (0.20–0.63)	<0.001
RSV + HRV	1.33 (1.02–1.73)	0.04
RSV + any other non-HRV pathogen	1.06 (0.67–1.69)	0.79
HRV + any other non-RSV pathogen	0.39 (0.23–0.66)	<0.001

Abbreviations: IQR indicates interquartile range; ABG, arterial blood gas; ICU, intensive care unit; RSV, respiratory syncytial virus; HRV, human rhinovirus.