Table 1.
Effects of baclofen on alcohol and tang seeking and self-administration under the CSR.
| A. Alcohol | Component 2 Link 1 (seeking) | Component 2 Link 2 (seeking) | Component 3 (self-administration) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Left Lever FI Resp | FI Resp Latency (s) | Left Lever FR Resp | Right Lever Resp | Drink contacts | Right Lever Resp | Drinks | Volume (ml) | Alcohol (g/kg) | |
| Baclofen (mg/kg) | |||||||||
| V | 93.3 (58.2) | 607.7 (3.0) | 10.0 (0.0) | 0.1 (0.1) | 0.0 (0.0) | 131.3 (12.5) | 15.3 (1.0) | 587.5 (44.3) | 1.0 (0.1) |
| 0.1 | 207.8 (136.9) | 609.4 (3.9) | 10.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 132.3 (26.0) | 14.8 (1.5) | 583.8 (74.5) | 1.0 (0.1) |
| 0.3 | 103.8 (54.9) | 607.5 (4.7) | 10.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 163.8 (31.1) | 18.8 (2.1) | 693.8 (44.0) | 1.2 (0.1) |
| 0.56 | 141.0 (54.9) | 611.3 (4.0) | 10.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 166.3 (27.6) | 18.8 (1.5) | 722.5 (81.9) | 1.2 (0.1) |
| 1.0 | 103.0 (37.2) | 607.1 (4.4) | 10.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 127.8 (13.6) | 15.3 (1.9) | 597.5 (78.6) | 1.1 (0.2) |
| 1.8 | 185.0 (93.8) | 611.1 (4.8) | 10.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 73.5 (7.8) | 8.5 (1.3) | 330.6 (38.1) | 0.6 (0.1) |
| 2.4 | 292.8 (149.6) | 614.1 (5.5) | 10.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 65.0 (19.4) | 8.3 (2.7) | 330.0 (97.7) | 0.6 (0.2) |
| F1 | 0.7 | 0.4 | nc | nc | nc | 6.5 | 6.7 | 8.3 | 8.8 |
| B. Tang | Component 2 Link 1 (seeking) | Component 2 Link 2 (seeking) | Component 3 (self-administration) | |||||
|---|---|---|---|---|---|---|---|---|
| Left Lever FI Resp | FI Resp Latency (s) | Left Lever FR Resp | Right Lever Resp | Drink contacts | Right Lever Resp | Drink Contacts | Volume (ml) | |
| Baclofen (mg/kg) | ||||||||
| V | 137.6 (32.0) | 628.3 (8.0) | 10.0 (0.0) | 0.1 (0.1) | 0.0 (0.0) | 370.6 (28.1) | 37.0 (2.8) | 973.3 (19.4) |
| 0.1 | 120.8 (71.1) | 608.7 (3.9) | 10.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 374.4 (17.9) | 37.2 (1.8) | 990.0 (10.0) |
| 0.3 | 35.0 (31.5) | 731.3 (117.2) | 10.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 414.6 (26.5) | 41.4 (2.6) | 990.0 (10.0) |
| 0.56 | 18.8 (14.5) | 616.1 (2.5) | 10.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 382.8 (32.6) | 38.2 (3.3) | 990.0 (10.0) |
| 1.0 | 210.4 (58.8) | 619.3 (8.9) | 10.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 417.8 (42.8) | 41.6 (4.2) | 990.0 (10.0) |
| 1.8 | 215.8 (111.5) | 662.5 (50.2) | 10.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 371.2 (57.6) | 37.0 (5.7) | 905.0 (65.4) |
| 2.4 | 144.4 (126.1) | 729.5 (117.7) | 8.0 (2.0) | 0.0 (0.0) | 0.0 (0.0) | 298.5 (79.5) | 29.8 (8.0) | 743.8 (148.0) |
| F1 | 1.7 | 0.6 | nc | nc | nc | 2.6 | 2.2 | 3.2 |
Data shown are group means (±SEM) for vehicle (V) and each baclofen dose (mg/kg). FI, Fixed Interval; Resp, Response. Degrees of freedom were 6, 18 (Alcohol group) and 6, 23 (Tang group).
1
An underlined F ratio indicates a significant (p<0.05) ANOVA, nc=not calculated. Bolded numbers indicate a significant (p<0.05) Bonferroni pairwise comparison to vehicle.