Table 3. Mutational status of KRAS and other genes.
| Case | Primary site | Mutation status | Pre-FOLFOX metastatic site | Mutation status | Post-FOLFOX recurrence site | Mutation status |
|---|---|---|---|---|---|---|
| 1 | Rectum | KRAS G12D | — | — | Liver | KRAS G12D |
| 2 | Colon | KRAS G12D | Liver | KRAS G12D | Liver | KRAS G12D |
| 3 | Colon | KRAS G12D | Liver | KRAS G12D | Liver | KRAS G12D |
| 4 | Rectum | KRAS G12R | Local recurrence | KRAS G12R | Local recurrence | KRAS G12R |
| 5 | Rectum | KRAS G12D | — | — | Lung | KRAS G12D |
| 6 | Colon | WT | — | — | LN | WT |
| 7 | Rectum | KRAS G12S | Liver | KRAS G12S | Lung | KRAS G12S |
| Lung | KRAS G12S | |||||
| 8 | Rectum | WT | — | — | Lung | WT |
| 9 | Colon | WT | — | — | Liver | WT |
| 10 | Colon | KRAS G12A | Liver | KRAS G12A | Lung | KRAS G12A |
| Liver | KRAS G12A | Lung | KRAS G12A | |||
| Lung | WT | |||||
| 11 | Colon | KRAS G13D | Lung | KRAS G13D | Lung | KRAS G13D |
| 12 | Rectum | KRAS A146V | Liver | KRAS A146V | Liver | KRAS A146V |
| 13 | Rectum | KRAS G12V | Liver | KRAS G12V | Liver | KRAS G12V |
| Lung | KRAS G12V | |||||
| 14 | Rectum | KRAS G12D | Subcutaneous | KRAS G12D | Lung | KRAS G12D |
| 15 | Colon | WT | — | — | Local recurrence | WT |
| 16 | Rectum | KRAS G12S, PIK3CA E542K | Liver | KRAS G12S, PIK3CA E542K | Lung | KRAS G12S, PIK3CA E542K |
| 17 | Rectum | KRAS G12D | Lung | KRAS G12D | Lung | KRAS G12D |
| 18 | Colon | KRAS G12D | Liver | KRAS G12D | Lung | KRAS G12D |
| Lung | KRAS G12D | |||||
| 19 | Rectum | NRAS Q61H | Liver | NRAS Q61H | Lung | NRAS Q61H |
| 20 | Rectum | PIK3CA E542K | — | — | Local recurrence | PIK3CA E542K |
| 21 | Rectum | KRAS A146V | Liver | KRAS A146V | Lung | KRAS A146V |
| Lung | KRAS A146V |
Abbreviations: LN= lymph node; WT= wild-type.