Table 2. Univariate overall and recurrence-free survival analysis for clinicopathological features and protein markers.
|
Overall survival
|
Recurrence-free survival
|
|||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | P -value | HR | 95% CI | P -value |
| Clinicopathological | ||||||
| Gender (male vs female) | 1.44 | 0.81–2.55 | NS | 0.90 | 0.54–1.52 | NS |
| Age, years (>50 vs <50) | 1.19 | 0.65–216 | NS | 1.00 | 0.62–1.62 | NS |
| Ethnicity (Chinese vs non-Chinese) | 0.70 | 0.33–1.49 | NS | 0.88 | 0.50–1.53 | NS |
| Serum AFP, ng dl−1 (>20 vs <20 | 1.66 | 0.96–2.85 | 0.066 | 1.62 | 1.02–2.55 | 0.057 |
| Grade (I+II vs III+IV) | 0.70 | 0.30–1.64 | NS | 0.91 | 0.50–1.64 | NS |
| TNM stage (I+II vs III+IV) | 2.42 | 1.38–4.22 | 0.002 | 2.52 | 1.56–4.06 | 0.000 |
| Tumour size, cm (>5 vs <5) | 1.68 | 1.00–2.83 | 0.048 | 2.20 | 1.44–3.37 | 0.000 |
| Number (solitary vs multiple) | 1.21 | 0.70–2.68 | NS | 1.49 | 0.96–2.31 | NS |
| Satellitosis (yes vs no) | 3.01 | 1.58–5.72 | 0.001 | 3.34 | 1.93–5.79 | 0.000 |
| Vascular invasion (yes vs no) | 3.39 | 1.91–6.01 | 0.000 | 2.89 | 1.82–4.58 | 0.000 |
| Protein expression | ||||||
| P53 (positive vs negative) | 2.38 | 1.42–4.0 | 0.001 | 1.83 | 1.18–2.84 | 0.006 |
| Cyclin D1 (positive vs negative) | 1.67 | 0.99–2.82 | 0.049 | 1.04 | 0.68–1.60 | NS |
| CD31 (positive vs negative) | 1.85 | 1.04–3.29 | 0.033 | 1.67 | 1.06–2.63 | 0.026 |
| EGFR (positive vs negative) | 1.08 | 0.63–1.84 | NS | 0.97 | 0.63–1.51 | NS |
| Ki-67 (positive vs negative) | 3.16 | 1.11–8.99 | 0.031 | 2.05 | 0.74–5.65 | NS |
| β-catenin (positive vs negative) | 1.12 | 0.65–1.90 | NS | 1.10 | 0.72–1.68 | NS |
| E-cadherin (positive vs negative) | 1.99 | 1.00–3.97 | 0.045 | 1.37 | 0.83–2.26 | NS |
| AFP (positive vs negative) | 2.21 | 1.26–3.87 | 0.005 | 2.13 | 1.35–3.36 | 0.001 |
| Hepar-1 (positive vs negative) | 0.58 | 0.34–1.00 | NS | 0.71 | 0.46–1.09 | NS |
| CD10 (positive vs negative) | 1.13 | 0.66–1.94 | NS | 1.28 | 0.82–1.98 | NS |
| CD117 (positive vs negative) | 1.82 | 0.66–5.0 | NS | 1.16 | 0.74–3.48 | NS |
| CD133 (positive vs negative) | 1.41 | 0.56–3.55 | NS | 0.47 | 0.15–1.5 | NS |
| CD44 (positive vs negative) | 2.21 | 1.28–3.83 | 0.004 | 1.34 | 0.88–2.04 | NS |
Abbreviations: AFP=α-fetoprotein; CI=confidence interval; EGFR=epidermal growth factor receptor; HR=hazard risk ratio; NS=not significant; TNM=tumour-node-metastasis.
Univariate analysis, Cox proportional hazards regression model.