Table 2. CYP2D6 phenotype, hot flushes at 6 months and corresponding OR (95% CI) in controls on tamoxifen.

CYP2D6 phenotype	Hot flushes	No hot flushes	OR (95% CI)	OR (95% CI) *
Extensive (N=173)	87 (50.3%)	86 (49.7%)	Reference	Reference
Intermediate (N=24)	14 (58.3%)	10 (41.7%)	1.38 (0.58–3.29)	1.19 (0.48–2.95)
Poor (N=14)	4 (28.6%)	10 (71.4%)	0.40 (0.12–1.31)	0.40 (0.12–1.36)
P-trend			0.3	0.09

Abbreviations: CI=confidence interval; OR=odds ratio.

^*Adjusted for hormone replacement therapy, smoking status, and menopausal status.