Table 2.
Human chemokine receptor genes.
| Name | Conventional name | Chromosome | Gene size (kb) | Number of exons | Number of amino acids | Ligands |
|---|---|---|---|---|---|---|
| CXCR | ||||||
| CXCR1 | IL8R1; IL8RA; CMKAR1 | 2q35 | 4.15 | 2 | 350 | CXCL6, CXCL8, |
| CXCR2 | IL8R2; IL8RB; CMKAR2 | 2q35 | 11.96 | 4 | 360 | CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, CXCL8, MIF |
| CXCR2P1 | CXCR2P; IL8RBP | – | 1 | |||
| CXCR3A | IP10-R; MigR; CMKAR3; | Xq13.1 | 2.60 | 2 | 368 | CXCL4, CXCL4L1, CXCL9, CXCL10, CXCL11, |
| CXCR3B | IP10-R; MigR; CMKAR3; | – | – | 2 | 415 | |
| CXCR3-alt | – | – | 2 | 267 | ||
| CXCR4 | LAP3; LCR1 | 2q21 | 2.60 | 2 | 352, 356 | CXCL12, MIF |
| CXCR5 | BLR1; MDR15 | 11q23.3 | 12.43 | 2 | 372, 327 | CXCL13 |
| CXCR6 | BONZO; CD186 | 3p21.26 | 4.87 | 2 | 342 | CXCL16 |
| CCR | ||||||
| CCR1 | CKR1; CMKBR1; MIP1aR | 3p21 | 6.63 | 2 | 355 | CCL3, CCL3L1, CCL3L3, CCL5, CCL7, CCL14, CCL15, CCL16; CCL23, |
| CCR2A | CMKAR2; CD182; CKR2B | 3p21.31 | 7.18 | 2 | 374 | CCL2, CCL7, CCL8, CCL13, |
| CCR2B | CKR2B | – | – | 3 | 360 | |
| CCR3 | CKR3; CMKBR3 | 3p21.3 | 24.32 | 3 | 355 | CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL15, CCL24, CCL26, CCL28, |
| CCR4 | CKR4; CMKBR4; ChemR13 | 3p24 | 3.33 | 2 | 360 | CCL17; CCL22 |
| CCR5 | CMKBR5; CKR5 | 3p21.23 | 6.06 | 3 | 352 | CCL3, CCL3L1, CCL3L1, CCL4, CCL4L1, CCL4L2, CCL5, CCL7, CCL11, CCL13 |
| CCR6 | BN-1; DCR2; CKR-L3 | 6q27 | 27.33 | 3 | 374 | CCL20 |
| CCR7 | BLR2; CMKBR7; EBI1 | 17q12-q21.2 | 11.71 | 3 | 378 | CCL19, CCL21 |
| CCR8 | CKRL1; CMKBR8; CMKBTER1 | 3p22 | 3.97 | 2 | 355 | CCL1 |
| CCR9A | GPR-9-6; GPR28 | 3p21.3 | 16.67 | 4 | 359 | CCL25 |
| CCR9B | GPR-9-6; GPR28 | – | – | – | 357 | CCL25 |
| CCR10 | GPR2 | 17q21.1-q21.3 | 2.42 | 2 | 362 | CCL27, CCL28 |
| XCR | ||||||
| XCR1 | CCXCR1; GPR5 | 3p21.3 | 7.68 | 2 | 333 | XCL1, XCL2 |
| CX3CR | ||||||
| CX3CR1 | CMKDR1; GPR13; CCRL1 | 3p21.3 | 18.24 | 4 | 355, 387, 362 | CX3CL1 |
| DECOYRECEPTORS | ||||||
| CXCR7 | RDC1; GPR159 | 2q37.3 | 12.61 | 2 | 362 | CXCL11, CXCL12, MIF |
| CCRL1 | CCR11; CCBP2; VSHK1; CCX-CKR; PPR1 | 3q22 | 5.29 | 2 | 350 | CCL19, CCL21, CCL25 |
| CCRL1P1 | dJ509I19.4 | 6q23.3 | 1 | |||
| CCRL2 | CKRX; CRAM-A; CRAM-B; HCR | 3p21 | 2.29 | 3 | 344, 256 | CCL5, CCL19 |
| CCBP2 | D6 | 3p21.3 | 57.81 | 3 | 384 | CCL2, CCL3, CCL4, CCL4L1, CCL4L2, CCL5, CCL7, CCL11, CCL13; CCL17, CCL22, |
| DARC | Duffy; FY | 1q21-q22 | 2.48 | 2 | 336, 338 | CCL2, CCL5, CCL7, CCL11, CCL13, CCL15, CCL17, CCL18, CCL22, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, CXCL8, CXCL11 |
| FORMYL PEPTIDE RECEPTOR | ||||||
| FPR2 | FPRL1; LXA4R; FMLP-R-II; FMLPX; FPR2A; FPRH1 | 19q13.3-q13.4 | 9.33 | 3 | 351 | CCL23, Lipoxin A4, serum amyloid A, β amyloid peptide Aβ42, SAA, MMK, Hp-(2-20) |
Human gene and protein data were taken from the web sitesEntrezGene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene and http://www.uniprot.org/, respectively.