Table 3.

Examples of chemokine/chemokine receptor single nucleotide polymorphisms (SNP) associated with cardiovascular diseases.

Gene	SNP	Associated with	p-Value	References
CCL2	rs1024611	Myocardial infarction	0.005 and 0.009a	McDermott et al. (2005)
			<0.001 and 0.001b
		Coronary artery disease	<0.005	Szalai et al. (2001)
CCL5	rs2107538	Acute coronary syndrome	0.0073	Simeoni et al. (2004)
		Coronary artery disease	0.0038
CCL11	rs1129844	Myocardial infarction	0.012 and 0.008c	Zee et al. (2004)
CXCL5	rs352046	Acute coronary syndrome	0.005	Zineh et al. (2008)
CXCL8	rs4073	Acute coronary syndrome	0.004	Zhang et al. (2011)
CXCL12	rs1746048	Myocardial infarction (early onset)	1 × 10−8	Kathiresan et al. (2009)
		Atherosclerosis severity and progression	0.009	Kiechl et al. (2010)
		Coronary artery disease	3 × 10−10	Schunkert et al. (2011)
	rs1801157	Myocardial infarction	0.007	Luan et al. (2010)
	rs501120	Coronary heart disease	1.4 × 10−6	Franceschini et al. (2011)
		Myocardial infarction	0.002	Qi et al. (2011)
		Coronary artery disease	9.46 × 10-8	Samani et al. (2007)
CCR2	rs1799864	Heart failure	0.015	Ortlepp et al. (2003)
		Myocardial infarction	0.007	Ortlepp et al. (2003)
			0.054d	Petrkova et al. (2003)
	rs34948438	Myocardial infarction	0.0013e	Karaali et al. (2010)
			0.0016f
CCR5	rs333	Myocardial infarction	0.001	Kallel et al. (2012)
			0.0013	Karaali et al. (2010)
		Severe calcific aortic stenosis	0.037g	Ortlepp et al. (2004)
		Myocardial infarction	0.003h	Singh et al. (2012)
CX3CR1	rs3732379	Coronary artery disease	0.03	McDermott et al. (2001)
		Acute coronary syndrome	0.001	Moatti et al. (2001)
		Single in-stent restenosis	0.006	Niessner et al. (2005)
		Recurrent in-stent restenosis	0.011
		Myocardial infarction	0.006i	Singh et al. (2012)

^aIn multivariable adjustment and multivariable adjustment of pooled-sex cohort, respectively.

^bIn multivariable adjustment and multivariable adjustment of male cohort, respectively.

^cIn an age and smoking and body mass index, hypertension, diabetes, and randomized treatment assignment adjusted recessive model of inherence, respectively.

^dIn female cohort.

^eIn patients carrying CCR5 rs34948438 wildtype (wt)/deletion (Δ) genotype.

^fIndividuals carrying the CCR5 rs34948438 heterozygote or homozygous variant genotype (Δ/Δ + wt/Δ).

^gIn patients carrying the CCR5 rs333 SNP or CTGF -447C allele.

^hIn individuals carrying both CCR5 rs1799987 and rs333 SNPs.

ⁱIn individuals carrying both CX3CR1 rs3732378 and rs3732379SNPs.