Table 2.
Brief summary of the different classes of phosphate binders
| Property | OsvaRen® | Renagel®/Renvela® |
e.g. CC-Nefro®, Dreisacarb® |
|---|---|---|---|
| Active compound class | Phosphate binder with reduced calcium content and proportion of magnesium (combination preparation) | Calcium-free phosphate binder | Calcium-containing phosphate binder |
| Active compound | Calcium acetate/magnesium carbonate | Sevelamer hydrochloride/ Sevelamer carbonate |
Calcium acetate Calcium carbonate |
| Licensed | October 2007 | April 2001/June 2009 | Since the late 1980s |
| Brand name | OsvaRen® film tablets | Renagel® 800 mg film tablets |
Calcium acetate: Calciumacetat-Nefro®, Calciumacetat Prorenal AM®, Phos-Ex®, amongst others Calcium carbonate: CC-Nefro®, Dreisacarb®, Calci-Gry®, amongst others |
| Manufacturer | Fresenius Medical Care | Genzyme Corporation | Various |
| Price/Packaging unit (Germany) | € 49.75 [23] | € 297.29 [23] | • Calciumacetat-Nefro® € 22.68, • Calciumacetat Prorenal AM® € 18.10, • Phos-Ex® € 27.69, • CC-Nefro® € 24.53, • Dreisacarb® € 24.53, • Calci-Gry® € 24.57 |
|
Dosing (Film tablets each day depending on the serum phosphate level) |
3-10 | 3-15 | • Calciumacetat-Nefro® 9-16, • Calciumacetat Prorenal AM® 9-16, • Phos-Ex® 8-16, • CC-Nefro® 12-18, • Dreisacarb® 6-12, • Calci-Gry® 1-2 |
| Price/day (Euro) | € 0.83 to € 2.76 | € 4.95 to € 24.77 | • Calciumacetat-Nefro® € 1.02-1.82, • Calciumacetat Prorenal AM® € 0.82-1.45, • Phos-Ex® € 1.11-2.22, • CC-Nefro® € 1.48-2.21, • Dreisacarb® € 0.74-1.48, • Calci-Gry® € 0.25-0.50 |
| Treatment cost/year (Euro) |
€ 300 to € 1,000 on average € 650 |
€ 1,800 to € 9,000 on average € 5,400 |
• Calciumacetat-Nefro® € 400-700, • Calciumacetat Prorenal AM® € 300-500, • Phos-Ex® € 400-800, • CC-Nefro® € 500-800, • Dreisacarb® € 300-500, • Calci-Gry® € 100-200 |