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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: J Neurochem. 2011 Sep 20;119(2):354–363. doi: 10.1111/j.1471-4159.2011.07364.x

Fig. 5.

Fig. 5

Effects of N-cadherin expression for alpha and beta-secretase cleavage. (a) The level of sAPPα released in the media was compared between the cells expressing pcDNA3.1 and NcadHA by ELISA (n.s.: p = 0.3519, n = 5). ADH-1 treatment of the NcadHA expressing cells did not affect the level of sAPPα (n.s.: p = 0.9045, n = 5). (b) The level of sAPPβ was significantly increased by the expression of NcadHA (*p < 0.001, n = 8). Treatment of cells with ADH-1 reduced sAPPb (**p < 0.0001, n = 8). (c) Analysis of ADAM10 and BACE1 expression by western blotting in cells expressing APP770 or co-expressing APP770 and N-cadherin.