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. 2012 May 25;31(13):3008–3019. doi: 10.1038/emboj.2012.158

Figure 6.

Figure 6

MDC1 sumoylation regulates MDC1 and Rad51 accumulation at DSBs. (A, B) MDC1−/− MEFs reconstituted with WT or K1840R FLAG-MDC1 were left untreated or irradiated (2 Gy) and probed with indicated antibodies at different time points; representative images are shown in (A); the quantification of the percentage of cells displaying Rad51 foci is shown in (B). Error bars represent s.e.m. from three independent experiments. (C, D) MDC1−/− MEFs reconstituted with WT or K1840R FLAG-MDC1 were left untreated or irradiated (2 Gy) and probed with indicated antibody at different time points. Representative images are shown in (C), the quantification of the percentage of cells displaying CtIP foci are shown in (D). Error bars represent s.e.m. from three independent experiments.