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Potential impact of levels/ratios of dNTP : rNTP in macrophages upon emergence of mutagenic HIV-1. Similar ratios of dNTP : rNTP (point 1) confer preferential incorporation of rNTP and rNMP into the growing viral DNA strand (point 2). Together, with suboptimal levels of repair machinery found in macrophages, these incorporations are a known correlate for production of mutagenic HIV-1 (point 3).
