Table 2.
Concentrations of CTP, GTP, ATP, UTP in activated or resting primary human macrophages versus lymphocytes. Concentrations of rNTPs are only 4–7-fold lower in macrophages versus lymphocytes independent of activation state [18, 25]. ±indicates standard deviation. Data represents at least five independent experiments performed with pooled cells from six independent donors.
| CTP | GTP | ATP | UTP | |
|---|---|---|---|---|
| μM | ||||
| Activated lymphocytes | 182 ± 24 | 1,745 ± 128 | 6,719 ± 560 | 690 ± 100 |
|
| ||||
| Activated macrophages | 27 ± 8 | 303 ± 60 | 1,011 ± 247 | 141 ± 17 |
|
| ||||
| Fold difference between activated lymphocytes versus activated macrophages | 7 | 6 | 7 | 5 |
|
| ||||
| Resting lymphocytes | 111 ± 30 | 923 ± 234 | 4,753 ± 896 | 453 ± 174 |
|
| ||||
| Resting macrophages | 25 ± 8 | 323 ± 95 | 1,124 ± 339 | 173 ± 47 |
|
| ||||
| Fold difference between resting lymphocytes versus resting macrophages | 4 | 3 | 4 | 3 |