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. Author manuscript; available in PMC: 2013 Jun 28.
Published in final edited form as: J Med Chem. 2012 Jun 7;55(12):5813–5825. doi: 10.1021/jm300234t

Table 3.

Maximun tolerated doses of mithramycin compounds

IV single
dose* 		IP single
dose* 		IV repeated
dose q2dx8* 		IV repeated
dose q3dx8*
1 2 mg/kg 6.25 mg/kg 0.6 mg/kgb 1.5 mg/kg
9 64 mg/kg 200 mg/kg 12 mg/kg 24 mg/kg
11 4 mg/kg 6.25 mg/kg ND ND
*

CD-1 mice received intraperitoneal (IP) or intravenous (IV) single injections or repeated injections of the compound every two days (q2dx8) or three days (q3dx8) for 8 days.

b

Literature data. ND, not determined.