Table 1. Effects of clioquinol and analogues on the viability of Raji cells.
Compounds | Structure | Drug alone IC50, μM | +ZnCl2 IC50, μM | +CuCl2 IC50, μM |
---|---|---|---|---|
Clioquinol | 5.09±020 | 3.30±0.38 | 1.89±0.25 | |
8-Hydroxy-5-nitroquinoline (NQ) | 0.438±0.20 | 0.855±0.18 | 0.0003±0.0 | |
5,7-Diiodo-8-hydroxyquinoline (IIQ) | 5.54±0.26 | 4.52±0.22 | 2.09±0.20 | |
5-Chloro-8-quinoline (CQ2) | 5.49±0.22 | 7.20±0.27 | 3.49±0.18 | |
8-Hydroxyquinoline (8HQ) | 1.98±0.23 | 6.92±0.14 | 0.03±0.002 | |
5,7-Dichloro-8-quinolinol (CCQ) | 1.44±0.15 | 1.40±0.2 | 0.133±0.03 | |
5-Amino-8-quinolinol dihydrochloride (A8HQ) | 5.44±0.13 | 8.56±0.15 | 1.93±0.10 |