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Scatter plot of patient number [adenocarcinomas of known EGFR and KRAS status (marked)] versus smoking status in pack-years. The vertical line separates ALK-positive from ALK-negative cases. ALK FISH positivity was statistically significantly enriched among never/light smokers (<10 pack-years; P = 0.0004, Fisher’s exact test; proportion positive among never/light smoking adenocarcinomas = 13 of 33, 39%; proportion positive among those with >10–pack-year smoking history = 0 of 22).
