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Chemical structures of small molecules reported to induce beta-cell proliferation. (a) 1-Azakenpaullone, a GSK-3β inhibitor [47]. (b) GKA50, a glucokinase activator [51]. (c) PSN632408, a GPR119 agonist [52]. (d) Bay K 8644, an L-type calcium channel activator [53]. (e) 5-Iodotubercidin, an adenosine kinase inhibitor [54].
