Table 5.

Common HSPB7-CLCNKA haplotypes, estimated population frequencies, and estimated associations with risk of all-cause mortality, cardiac transplantation, or ventricular assist device placement: Hazard ratio (HR) and 95% confidence interval (CI). Individual p values obtained from univariable Wald test to evaluate whether the hazard ratio is equal to 1; overall p value obtained from multivariable Wald test to evaluate whether all hazard ratios are equal to 1.

			Weighted estimation		Weighted combination
Label	Haplotype	Frequency	HR (95% CI)	p	HR (95% CI)	p
Q	AGAGCGAGACGAGG	0.036	1.19 (0.80, 1.77)	0.39	1.19 (0.76, 1.87)	0.44
R	AGAGCGAGGGAAGG	0.160	1.04 (0.80, 1.35)	0.79	1.05 (0.81, 1.37)	0.73
S	AGAGCGGAGCAAGA	0.036	1.20 (0.80, 1.77)	0.38	1.20 (0.74, 1.94)	0.47
T	AGCGAGAGGCAAGA	0.066	0.55 (0.34, 0.88)	0.014	0.53 (0.32, 0.90)	0.019
U	GACGCGGAGCGCGG	0.063	0.80 (0.53, 1.20)	0.28	0.80 (0.52, 1.21)	0.29
V	GGAACAAGGGAAGG	0.037	0.49 (0.26, 0.92)	0.025	0.43 (0.21, 0.88)	0.021
W	GGAACAGAGCAAGA	0.299	Referent		Referent
X	GGAACAGAGCAAGG	0.048	1.36 (0.95, 1.95)	0.089	1.44 (0.95, 2.19)	0.090
Y	GGAGCAAGGCAAGG	0.050	1.15 (0.78, 1.69)	0.49	1.15 (0.77, 1.72)	0.49
Z	GGCGCGGAGCAAGG	0.031	1.09 (0.62, 1.92)	0.76	1.10 (0.64, 1.87)	0.73
Overall				0.015		0.026