(a) Upregulated C. albicans genes
| ORFa | Gene | Molecular functionb | Log phase cocultures | Late log to early stationary phase cocultures | |||||
|---|---|---|---|---|---|---|---|---|---|
| GR1_a | RC14_a | GR1_b | GR1_c | GR1_d | RC14_b | GR1_e | |||
| Amino acid metabolismc | |||||||||
| orf19.5610 | ARG3 | Ornithine carbamoyltransferase | 0.49 | 2.43 | −0.53 | 1.69 | 3.54† | 4.36† | 3.20† |
|
| |||||||||
| Carbohydrate metabolism | |||||||||
| orf19.3675 | GAL7 | Putative galactose-1-phosphate uridyl transferase | 0.69 | 2.12 | 1.55 | 6.12† | 3.40† | 4.11† | 0.47 |
| orf19.1788 | XKS1 | Putative xylulokinase | 0.39 | 2.26 | 0.37 | 3.24† | 2.91 | 4.33† | 3.06† |
|
| |||||||||
| Cell wall biosynthesis | |||||||||
| orf19.3688 | Putative chromatin DNA binding protein | 7.69† | 1.66 | 0.35 | 0.19 | 10.34† | 4.25† | −0.09 | |
| orf19.3674 | GAL102 | UDP-glucose 4,6-dehydratase with role in mannosylation of cell wall proteins | 0.11 | 1.70 | −0.06 | 3.63† | 4.48† | 4.75† | 0.21 |
|
| |||||||||
| Fatty acid metabolism | |||||||||
| orf19.5640 | PEX5 | Putative peroxisomal targeting receptor | 0.14 | −2.14 | 3.31† | 5.21† | 3.34† | 4.03† | 1.03 |
| orf19.5215 | TES15 | Putative acyl-CoA thioesterase | −0.91 | −0.76 | 1.91 | 3.58† | 5.17† | 5.66† | −2.00 |
|
| |||||||||
| Glycogen metabolism | |||||||||
| orf19.3302 | Putative type-1 protein phosphatase targeting subunit | −0.61 | −0.98 | 0.58 | 3.03† | 6.26† | 3.28† | 1.32 | |
|
| |||||||||
| Glycolysis | |||||||||
| orf19.6116 | GLK4 | Glucokinase | −0.85 | 0.48 | 1.25 | 0.82 | 4.13† | 3.05† | 6.62† |
|
| |||||||||
| Intracellular transport | |||||||||
| orf19.3233 | HSE1 | Putative SH3-domain-containing protein | −1.94 | −0.81 | 2.30 | 3.34† | 5.24† | 3.66† | −0.24 |
| orf19.7086 | Putative protein transporter | 0.54 | −1.18 | −1.10 | 1.35 | 4.74† | 4.15† | 3.27† | |
| orf19.3841 | Putative protein serine/threonine kinase | −2.91 | −0.82 | −0.68 | 4.07† | 4.94† | 4.92† | −1.58 | |
|
| |||||||||
| Oxidation/Reduction | |||||||||
| orf19.5805* | DLD1* | D-lactate dehydrogenase* | 1.34 | 0.72 | 4.57† | 3.63† | 6.23† | 5.90† | 8.57† |
| orf19.1048 | IFD6 | Aldo-keto reductase | −0.09 | 2.07 | 1.36 | −0.92 | 5.16† | 3.41† | 6.71† |
| orf19.742 | ALD6 | Putative aldehyde dehydrogenase | −1.27 | 0.96 | −0.19 | 4.46† | 4.77† | 5.36† | 3.16† |
| orf19.5288 | IFE2 | Alcohol dehydrogenase | 1.03 | −0.07 | −0.66 | 5.77† | 6.75† | 6.04† | 0.33 |
|
| |||||||||
| Protein catabolism | |||||||||
| orf19.1191 | Possible ubiquitin-protein ligase | 1.12 | −0.91 | 3.14† | 2.25 | 3.64† | 4.31† | −0.45 | |
| orf19.5752 | Possible ubiquitin-protein ligase | −1.59 | −0.66 | 0.17 | 4.35† | 3.16† | 3.29† | 2.38 | |
|
| |||||||||
| Repair | |||||||||
| orf19.1331 | HSM3 | Protein may be involved in DNA mismatch repair | −0.74 | −2.27 | −0.14 | 4.18† | 8.78† | 6.68† | 5.39† |
|
| |||||||||
| Respiration | |||||||||
| orf19.4551 | CTN1 | Predicted carnitine acetyl transferase | 1.21 | 1.97 | 0.08 | 11.85† | 3.64† | 7.52† | 2.61 |
|
| |||||||||
| RNA catabolism | |||||||||
| orf19.5614 | RNH1 | Putative ribonuclease H1 | −1.33 | 0.38 | −0.07 | 3.06† | 4.11† | 2.96 | 3.22† |
|
| |||||||||
| Signaling | |||||||||
| orf19.399 | Putative serine/threonine protein kinase | −2.21 | −2.59 | −0.10 | 4.08† | 4.88† | 4.44† | −0.22 | |
| orf19.5531 | CDC37 | Chaperone for Crk1 protein kinase | −0.45 | 0.95 | 0.80 | 2.13 | 5.46† | 3.19† | 6.05† |
|
| |||||||||
| Stress response | |||||||||
| orf19.882* | HSP78* | Heat-shock protein* | 0.00 | −1.35 | 0.06 | 4.21† | 4.52† | 5.81† | 4.66† |
| orf19.3861* | SIS1* | Putative Type II HSP40 co-chaperone* | −0.91 | −0.40 | 0.79 | 1.65 | 3.92† | 4.78† | 3.10† |
| orf19.5348* | TPS3* | Trehalose-phosphate synthase subunit* | 0.59 | −0.26 | −0.99 | 4.23† | 8.95† | 7.42† | 5.40† |
|
| |||||||||
| Transcriptional regulation | |||||||||
| orf19.3047 | SIP3 | Protein kinase-related protein | 1.23 | 0.77 | 0.66 | 3.62† | 3.69† | 4.84† | 4.52† |
| orf19.909 | STP4 | Putative transcription factor | −0.52 | −1.28 | 1.29 | 6.75† | 5.15† | 7.01† | 2.41 |
| orf19.3190 | HAL9 | Putative transcription factor involved in salt tolerance | 0.98 | 1.83 | 2.82 | 3.87† | 4.99† | 5.03† | −0.59 |
|
| |||||||||
| Translation | |||||||||
| orf19.154 | Possible 90S pre-ribosome complex protein | 9.04† | 1.52 | −0.03 | 4.19† | 3.22† | 2.77 | 0.90 | |
|
| |||||||||
| Transport | |||||||||
| orf19.5079* | CDR4* | ABC transporter* | 2.77 | 3.79† | −0.06 | 3.22† | 2.89 | 3.51† | 1.78 |
| orf19.4802 | FTH1 | Putative high affinity iron transporter (vacuolar) | −0.45 | 0.76 | 1.10 | 4.54† | 5.95† | 7.85† | −0.38 |
| orf19.3668 | HGT2 | Putative glucose transporter | 1.17 | 1.35 | 1.73 | 9.56† | 4.30† | 3.16† | −2.49 |
| orf19.5447 | HGT19 | Putative glucose/myo-inositol transporter | 2.51 | 3.11† | 2.55 | 4.67† | 2.95 | 5.05† | 5.41† |
| orf19.3526 | ITR1 | Inositol transporter | 1.82 | −0.20 | 1.69 | 3.52† | 5.21† | 5.25† | 2.91 |
| orf19.1979 | GIT1 | Putative glycerophosphoinositol permease | 0.97 | 6.75† | −1.94 | 3.73† | 5.82† | 8.01† | 1.64 |
| orf19.1027 | PDR16 | Phosphatidylinositol transfer protein | −0.47 | −1.63 | 0.61 | 2.19 | 3.61† | 4.23† | 3.05† |
| orf19.4737* | TPO3* | Possible polyamine transporter* | 0.08 | −0.02 | 3.65† | 4.30† | 4.59† | 7.16† | 3.48† |
| orf19.700* | SEO1* | Similar to permeases (↑weak acid stress)* | −0.79 | −1.34 | 4.50† | 4.90† | 2.88 | 5.02† | −0.14 |
|
| |||||||||
| Unknown | |||||||||
| orf19.2498 | Unknown | −2.12 | −1.08 | 0.29 | 3.03† | 3.05† | 3.99† | −0.55 | |
| orf19.5245 | Unknown | −0.36 | −1.74 | 1.59 | 0.84 | 5.03† | 5.24† | 4.78† | |
| orf19.6321 | PGA48 | Putative GPI-anchored protein of unknown function | −1.55 | −0.79 | 0.71 | −1.46 | 5.14† | 3.50† | 3.62† |
| orf19.5295 | Unknown | −0.76 | 1.02 | −2.03 | 5.83† | 3.06† | 3.51† | −1.02 | |
| orf19.3448 | Unknown | 1.02 | 0.86 | −0.59 | 5.89† | 2.51 | 3.32† | 3.52† | |