(b) C. albicans genes with mixed regulation
| ORFa | Gene | Molecular functionb | Log phase cocultures | Late log to early stationary phase cocultures | |||||
| GR1_a | RC14_a | GR1_b | GR1_c | GR1_d | RC14_b | GR1_e | |||
|
| |||||||||
| Amino acid metabolismc | |||||||||
| orf19.3974 | PUT2 | 1-Pyrroline-5-carboxylate dehydrogenase | −4.32# | −0.86 | −0.39 | 3.07† | −3.25# | −6.02# | −1.68 |
| orf19.105 | HAL22 | Put. phosphoadenosine-5′-phosphate phosphatase | −2.16 | −4.51# | 3.44† | 3.62† | −0.79 | 3.67† | −3.38# |
| orf19.5811 | MET1 | Putative uroporphyrin-3 C-methyltransferase | 0.37 | 0.59 | 0.67 | 4.93† | −1.93 | 3.53† | −4.15# |
|
| |||||||||
| Carbohydrate metabolism | |||||||||
| orf19.7481 | MDH1 | Malate dehydrogenase | −1.68 | −2.14 | 1.19 | 3.97† | −3.66# | −3.34# | −1.21 |
|
| |||||||||
| Cell morphogenesis | |||||||||
| orf19.4892 | TPK1 | Subunit of cAMP-dependent protein kinase (PKA) | 0.19 | 1.68 | −3.02# | −1.85 | 2.69 | 3.01† | −3.77# |
|
| |||||||||
| Cell wall assembly | |||||||||
| orf19.377 | PHR3 | Putative beta-1,3-glucanosyltransferase | −1.11 | 0.74 | 3.09† | 3.46† | 1.67 | 1.60 | −3.52# |
|
| |||||||||
| Cytoskeleton maintenance | |||||||||
| orf19.3505 | Similar to S. cerevisiae phosphoinositide binding protein Slm2 | −0.04 | −4.18# | −1.26 | 0.59 | 5.35† | 3.91† | 0.07 | |
|
| |||||||||
| Filamentous growth | |||||||||
| orf19.4246 | Similar to S. cerevisiae Ykr070w protein | −1.10 | −4.36# | 0.89 | 4.67† | 3.16† | 2.66 | 3.93† | |
| orf19.860 | BMT8 | Putative beta-mannosyltransferase | −4.31# | 1.93 | 3.88† | 1.90 | −3.35# | −2.13 | −0.42 |
|
| |||||||||
| Oxidation/reduction | |||||||||
| orf19.7323 | CBP1 | Corticosteroid binding protein | −1.74 | 3.42† | 0.83 | 0.26 | −3.66# | −3.27# | −1.81 |
| orf19.6139 | FRE7 | Putative ferric reductase | −1.25 | 0.17 | 4.56† | −2.56 | −3.14# | −4.12# | −0.42 |
| orf19.6531 | NUC2 | NADH-ubiquinone oxidoreductase | −2.95 | 0.14 | 3.33† | −2.10 | −3.89# | −4.12# | −1.28 |
|
| |||||||||
| pH response | |||||||||
| orf19.101 | RIM9 | Unknown, involved in cellular response to pH | −0.73 | −0.50 | −0.84 | 2.43 | 3.69† | 3.75† | −3.08# |
|
| |||||||||
| Stress response | |||||||||
| orf19.3707* | YHB1* | Nitric oxide dioxygenase* | −0.61 | −1.54 | 1.07 | 4.53† | 2.61 | 5.15† | −3.06# |
| orf19.6232* | NPR1* | Predicted serine/threonine protein kinase* | −3.75# | −1.63 | 4.49† | 3.98† | −0.21 | 1.51 | −0.30 |
|
| |||||||||
| Transcription | |||||||||
| orf19.2831 | RPC31 | Putative RNA polymerase III subunit C31 | −0.70 | 3.18† | 2.42 | −3.33# | −3.63# | −2.32 | −1.66 |
| orf19.5908 | TEC1 | TEA/ATTS transcription factor | 2.31 | 2.20 | 1.74 | 6.57† | 1.81 | 4.84† | −4.97# |
| orf19.5992 | WOR2 | Transcriptional regulator of white-opaque switching | −1.25 | −3.19# | −0.42 | 6.58† | 6.05† | 8.17† | −3.00# |
|
| |||||||||
| Transport | |||||||||
| orf19.6578 | Predicted membrane transporter | 0.28 | −3.37# | −0.56 | 4.20† | 6.39† | 3.27† | 0.01 | |
|
| |||||||||
| tRNA aminoacylation | |||||||||
| orf19.5239 | similarity to alanyl-tRNA synthases | 0.30 | −4.73# | −3.55# | 0.74 | 0.58 | 3.76† | 0.69 | |
|
| |||||||||
| Unknown | |||||||||
| orf19.925 | −1.03 | −1.59 | 3.42† | −0.81 | −4.07# | −3.38# | 0.11 | ||
| orf19.599 | 2.89 | 4.04† | 4.02† | −3.40# | 0.51 | 0.33 | 2.02 | ||
| orf19.4765 | PGA6 | Putative GPI-anchored cell wall adhesin-like protein | −0.67 | 5.78† | −3.74# | −0.92 | −0.13 | −4.12# | 2.61 |
| orf19.6342 | 2.06 | 4.26† | −3.63# | −3.94# | 1.70 | 2.11 | 1.27 | ||