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Type I collagen protects HT1080 cells against the antimigratory effect of doxorubicin. The seeded cells on plastic, on 2D coating or inside 3D matrices, were exposed to subtoxic concentrations of doxorubicin (5 and 10 nM) for 24 h. Cell motility was examined for the last 12 h using time-lapse videomicroscopy as described before [15, 16].
| Migration speed (μm/h) | |||
|---|---|---|---|
| 2D plastic | 2D coating | 3D matrix | |
| Control | 15.6 ± 1.4 | 19.0 ± 0.7 | 24.8 ± 0.9 |
| Doxorubicin | 8.3 ± 0.8 | 23.0 ± 1.1 | 25.7 ± 1.5 |
