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. Author manuscript; available in PMC: 2012 Jul 12.
Published in final edited form as: Neurourol Urodyn. 2011 Jan;30(1):144–150. doi: 10.1002/nau.20965

Figure 4. β3AR agonists decrease baseline tone and spontaneous activity of bladder strips with and without the urothelium.

Figure 4

A. TAK-677 decreases baseline tone and amplitude of spontaneous contractions in a concentration dependent manner in strips without (i) and with (ii) the urothelium. Isoproterenol (iso), a nonspecific βAR agonist, further decreases the baseline tone and the amplitude of the contractions in the presence of a maximal concentration of TAK-677. Examples are from strips from the same bladder. B-C. Summary of the effects of TAK-677 on baseline tone (B) and on amplitude of spontaneous contractions (C) in strips without (n=23 strips from 13 animals; black bars) and with (n=27 strips from 17 animals; grey bars) the urothelium. D-E. Summary of the effects of BRL37344 on baseline tone (D) and on amplitude of spontaneous contractions (E) in strips without (n=11 strips from 7 animals; black bars) and with (n=22 strips from 11 animals; grey bars) the urothelium. Asterisk indicates statistically significant differences between the effect of the agonist and control (ANOVA followed by Tukey-Kramer Multiple Comparisons Test; ***p<0.001; **p<0.01; *p<0.05). Values are expressed as mean ± SEM.