Table 1.
Summary of rat model histopathological scores.
| Factor (scores) | DMN | DMN + GP | DMN + Silymarin | GP | Control | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1-2 wk | 3-4 wk | 5-6 wk | 2 wk | 3-4 wk | 5-6 wk | 2 wk | 3-4 wk | 5-6 wk | 2–6 wk | 1–6 wk | ||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n(%) | n (%) | n (%) | n (%) | n (%) | ||
| Necroinflammatory | A0 | 0 (0) | 1 (9) | 4 (44) | 3 (50) | 4 (45) | 9 (64) | 0 (0) | 2 (22) | 2 (20) | 10 (100) | 100 (24) |
| A (1–3) | 5 (62.5) | 3 (27) | 4 (44) | 3 (50) | 2 (22) | 1 (7) | 3 (75) | 3 (33) | 2 (20) | 0 (0) | 0 (0) | |
| A (4–6) | 3 (36.5) | 7 (64) | 1 (12) | 0 (0) | 3 (33) | 4 (29) | 1 (25) | 4 (45) | 6 (60) | 0 (0) | 0 (0) | |
|
| ||||||||||||
| Fibrosis | F (0-1) | 6 (75) | 1 (9) | 2 (22) | 6 (100) | 8 (67) | 7 (50) | 3 (75) | 3 (33) | 0 (0) | 10 (100) | 100 (24) |
| F (2-3) | 2 (25) | 10 (91) | 7 (78) | 0 (0) | 4 (33) | 7 (50) | 1 (25) | 6 (67) | 10 (100) | 0 (0) | 0 (0) | |
|
| ||||||||||||
| Fatty change | − | 7 (87.5) | 11 (100) | 9 (100) | 6 (100) | 12 (100) | 14 (100) | 4 (100) | 8 (89) | 10 (100) | 10 (100) | 100 (24) |
| + | 1 (12.5) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (11) | 0 (0) | 0 (0) | 0 (0) | |
Results are ranked by time course. Necroinflammatory change was scored as A (0), no change; A (1–3), mild; A (4–6), moderate necroinflammation. Fibrosis was graded as F (0-1) for observations ranging from normal tissue to fibrous expansion of portal tracts and F (2-3) for bridge fibrosis to frequent bridging fibrosis with nodule formation. The fatty change was classified by its presence or absence (+/−). The number of rats was counted and used to calculate the percentage of each histopathological level at each time point.
n: number of rats.