Table 2.
SERT Genotype | Randomization group | Number of participants | N (%) in remission | Mean % reduction in HDRS | Std. Deviation | Std. Error Mean | T (df) | P-value (two tailed) |
---|---|---|---|---|---|---|---|---|
5-HTTLPR | ||||||||
l/l | Intervention | 10 | 1 (10%) | −32.27 | 22.59 | 7.14 | − .622 (19) | 0.54 |
Control | 11 | 1 (9%) | −25.70 | 25.46 | 7.68 | |||
s/l | Intervention | 12 | 5 (42%) | −47.06 | 23.85 | 6.89 | −2.53 (20) | 0.02 |
Control | 10 | 2 (20%) | −15.90 | 33.88 | 10.71 | |||
s/s | Intervention | 8 | 7 (85%) | −62.78 | 11.18 | 3.95 | −3.8 (16) | 0.002 |
Control | 10 | 3 (30%) | −27.20 | 24.32 | 7.69 | |||
STin2 VNTR | ||||||||
10/10 | Intervention | 5 | 1 (20%) | −22.49 | 30.20 | 13.51 | −0.88 (4) | 0.43 |
Control | 1 | 0 (0%) | 6.67 | . | . | |||
9/10 or 10/12 | Intervention | 11 | 3 (27%) | −44.99 | 10.49 | 3.16 | −2.2 (21) | 0.37 |
Control | 12 | 2 (16%) | −26.85 | 25.11 | 7.25 | |||
9/12 or 12/12 | Intervention | 14 | 9 (64%) | −55.87 | 23.19 | 6.19 | −3.5 (30) | 0.001 |
Control | 18 | 4 (22%) | −22.12 | 29.59 | 6.97 |
Note: For each SERT polymorphism (5-HTTLPR and STin2 VNTR) the number of participants in intervention and control groups are shown. The middle columns give the number and percentage of these subjects in remission after 9 weeks (Hamilton Depression Rating Scale, HDRS, score of <10 as a surrogate for remission), the mean % reduction in their HDRS scores over the same time span, as well as standard deviation and standard error of the mean HDRS change over time. Results of the statistical analysis are shown to the right (df = degrees of freedom).