Table 1.
Author | Main objective | Power calculation | Intervention | Control | Acupuncture juncture | CPR | LBR | Analysis | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MA | EA | LA | Sham Acu. at acupoints | Sham Acu. at non- or inappropriate points | NT or RX | Sham LA | Adhesive tapes | |||||||
(1) Paulus et al. [21] | IVF outcome | No | √ | √ | A | √ | ITT | |||||||
(2) Paulus et al. [22] | IVF outcome | No | √ | √ | A | √ | ITT | |||||||
(3) Smith et al. [23] | IVF outcome | Yes | √ | √ | A | √ | ITT | |||||||
(4) Westergaard et al. [24] | IVF outcome | Yes | √ (2) | √ | A | √ | TPP | |||||||
(5) Dieterle et al. [25] | IVF outcome | Yes | √ | √ | A | √ | ITT | |||||||
(6) Benson et al. [26] | IVF outcome | No | √ | √ | √ (2) | √ | A | √ | ITT | |||||
(7) Craig et al. [27] | IVF outcome | No | √ | √ | A | √ | TPP | |||||||
(8) Cui et al. [28] | IVF outcome | No | √ | √ | C | √ | ITT | |||||||
(9) Fratterelli et al. [29] | IVF outcome | Unclear | √ | √ | √ (2) | √ | A | √ | √ | ITT | ||||
(10) Chen et al. [30] | IVF outcome | No | √ | √ | C | √ | ITT and TPP | |||||||
(11) Domar et al. [31] | IVF outcome, | No | √ | √ | A | √ | ITT | |||||||
(12) Ho et al. [32] | IVF outcome | No | √ | √ | C | √ | ITT | |||||||
(13) So et al. [33] | IVF outcome | Yes | √ | √ | A | √ | √ | ITT | ||||||
(14) So et al. [34] | IVF outcome | Yes | √ | √ | A | √ | √ | ITT | ||||||
(15) Andersen et al. [35] | IVF outcome | Yes | √ | √ | A | √ | √ | ITT and TPP | ||||||
(16) Madaschi et al. [36] | IVF outcome | Yes | √ | √ | A | √ | √ | ITT | ||||||
(17) Arnoldi et al. [37] | IVF outcome | Unclear | √ | √ | C | √ | ITT and TPP | |||||||
(18) Moy et al. [38] | IVF outcome | Yes | √ | √ | A | √ | TPP | |||||||
(19) Cui et al. [39] | IVF outcome | No | √ | √ | C | √ | TPP | |||||||
(20) Stener-Victorin et al. [3] | Pain relief | No | √ | √ | B | √ | √ | TPP | ||||||
(21) Stener-Victorin et al. [40] | Pain relief | Yes | √ | √ | B | √ | TPP | |||||||
(22) Humaidan and Stener-Victorin [41] | Pain relief | Yes | √ | √ | B | √ | TPP | |||||||
(23) Sator-Katzenschlager et al. [42] | Pain relief | Yes | √ | √ | √ | B | √ | TPP | ||||||
| ||||||||||||||
Total | 19 IVF outcome, 4 Pain relief | 11 yes | 16(17) | 8 | 2 | 4 | 3 | 15(17) | 2 | 1 | 14A 4B 5C | 23 | 6 | 15 ITT, 11 TPP |
Note: MA: manual acupuncture; EA: electroacupuncture; LA: laser acupuncture; Acu.: acupuncture. NT: non intervention treatment; RX: relaxation. A: acupuncture was used around the time of embryo transfer (ET); B: acupuncture was used around the time of oocyte aspiration (OA); C: acupuncture was mainly performed during the course of controlled ovarian hyperstimulation (COH); CPR: clinical pregnancy rate; LBR: live birth rate; Westergaard 2006 MA (2): two MA groups; Benson 2006, Fratterelli 2008 NT, or RX (2): two controlled groups. ITT: intention to treat analysis; TPP: treated-per-protocol analysis.