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LDL-cholesterol values (mean, 95 % confidence interval) in the LIPID trial. A clear difference between pravastatin and placebo was observed in the double blind, randomized phase of the study (mean duration: 6 years) while the difference disappeared in the open-label, observational, post-trial follow up (duration: 2 years). (From Lancet 2002; 359:1379–1387, with permission).
