Figure 7.

snapin genetically interacts with snap25 but not dynein intermediate chain during synaptic homeostasis. A, No genetic interaction is observed between a snapin deficiency (Df(2L)Exel6277) and a strong loss-of-function allele of dynein intermediate chain (dic¹²²⁹) when the NMJ is challenged following PhTx application (p > 0.05, Student's t test and ANOVA). B, Strong genetic interaction between the snapin deficiency and a null mutation in snap25 (snap25^mx124), where there is no increase in quantal content following PhTx application (p < 0.0037, Student's t test and ANOVA). Synaptic homeostasis can be restored when snapin is expressed in motorneurons (c155-GAL4/Y; snap25^mx124/snapin^{DF(2L)Exel6277}; UAS-snapin/+). Synaptic homeostasis is robustly expressed in mutants in the Bloc-1 subunit blos1 (w; blos1^ex2). Error bars are SEM.