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. 2012 Jul 12;8(7):e1002585. doi: 10.1371/journal.pcbi.1002585

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Francois et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Sketch of the model. Parameters and equations are given in Supplementary Text S1 (B) Variation of the period as a function of input. (C) limit cycle for different values of the input in space. Limit cycle varies over one order of magnitude in variable 1 and 2 while the period changes at most (D) Rescaling of those limit cycle to the unit interval for each variable. The orbits for different inputs no longer scale. Circles mark the fixed point (E)The PRC for different input values do not scale. The PRC was computed by adding a degradation term of for variable 2 for of the period. (F) Variable as a function of phase for the limit cycles at different temperature. Its rescaled maximum of 1 is defined as phase for the PRC.

Inline graphic — (A) Sketch of the model. Parameters and equations are given in Supplementary Text S1 (B) Variation of the period as a function of input. (C) limit cycle for different values of the input in space. Limit cycle varies over one order of magnitude in variable 1 and 2 while the period changes at most (D) Rescaling of those limit cycle to the unit interval for each variable. The orbits for different inputs no longer scale. Circles mark the fixed point (E)The PRC for different input values do not scale. The PRC was computed by adding a degradation term of for variable 2 for of the period. (F) Variable as a function of phase for the limit cycles at different temperature. Its rescaled maximum of 1 is defined as phase for the PRC.