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. 2012 Jul 12;8(7):e1002797. doi: 10.1371/journal.ppat.1002797

Figure 2. Structure of trimeric HIV-1 BaL Env bound to VRC01 and VRC03 antibodies.

Figure 2

(a–d) Slices through reconstructed cryo-electron tomograms of HIV-1 BaL in the unliganded state (a) or complexed with VRC01 (b), VRC02 (c) or VRC03 antibodies (d). Peripheral Env glycoprotein spikes are visible on the viral membrane. Scale bar is 100 nm. (e, f) Top and side views, respectively, of the VRC01-bound HIV-1 BaL Env density map fitted with X-ray coordinates of the gp120-VRC01 Fab complex (PDB ID:3NGB). (g, h) Top and side views, respectively, of the VRC03-bound Env density map fitted with X-ray coordinates for gp120-VRC03 Fab (PDB ID:3SE8). Coordinates show gp120 (red), VRC01 (blue) and VRC03 (black). In panels (e) and (g), the locations of the stumps of the V1V2 loop are shown by the red ovals.