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. 2012 Jul 12;8(7):e1002797. doi: 10.1371/journal.ppat.1002797

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(a) Side view of the structure of trimeric Env bound to 17b Fab. The map was fitted with three copies of the X-ray structures for the gp120-17b portion of the 1GC1 coordinates with gp120 (red) and 17b Fv fragments (light chain: yellow, heavy chain: green). One copy of the gp41 N-terminal helix (cyan) of 1AIK coordinates (N34) was fitted individually into each of the three densities, which occupy the central region of the spike that is essentially a cavity in the unliganded state. (b) Side view of the density map from unliganded native trimeric Env [21], [22], [23], [24], with the three gp41 N-terminal helices (cyan) superposed to show that in the open conformation, they occupy the solvent filled cavity in the density map of the unliganded state.