Table 1. Patient demographics, clinical parameters and study participation of subjects completing neurocognitive testing (NCT) procedures.
StudyParticipation | Clinical parameter | Acute HCV/HIV(aHCV) | HIV monoinfection(HIVmono) | Difference betweengroups, p-value* |
Overall | Number, n | 24 | 57 | |
Age (years), median [IQR] | 41 [36], [44] | 47 [39, 56] | 0.003 | |
Male gender, n (%) | 24 (100) | 50 (89) | 0.10 | |
Time-elapsed since HIV diagnosis (years), median [IQR] | 6 [3], [12] | 11 [5], [16] | 0.02 | |
Current CD4+(cells/µL), median [IQR] | 590 [458, 745] | 505 [382, 783] | 0.29 | |
Nadir CD4+(cells/µL), median [IQR] | 200 [215, 395] | 205 [88, 283] | 0.01 | |
Receiving antiretroviral therapy, n (%) | 17 (71) | 54 (95) | 0.006 | |
Current plasma HIV viral load below 50 c/mL, n (%) | 16 (67)† | 54 (95) | 0.002 | |
HIV viral load of remaining subjects (c/mL), median [IQR] | 5797 [1136, 11758] | 14182 [1095, 15952] | 0.18 | |
Time elapsed since negative HCV RNA test (weeks), median [IQR] | 24 [20], [32] | – | – | |
Current ALT (IU), median [IQR] | 213 [78, 237] | – | – | |
Peak ALT (IU), median [IQR] | 237 [180, 820] | – | – | |
HCV genotype 1, n (%) | 21 (88) | – | – | |
Most recent HCV RNA (c/mL), median [IQR] | 986855 [56650, 4315528] | – | – |
Table 1 legend: HCV = hepatitis C virus; RNA: ribonucleic acid; ALT = alanine aminotransferase; IU = international units;
1 subject had VL 87 copies/mL at time of assessment, repeat <50 copies/mL, *using Fisher’s exact test or t-test].