Table 2. Results of cerebral function assessments and univariate regression analysis to investigate differences between subject groups.

Cerebral functionassessment,mean (SD)			AcuteHCV/HIV(aHCV)	HIVmonoinfection(HIVmono)	p-value	[95%CI]
NCT	Number of participants, n		24	57
	Participants on cART, n(%)		17 (71%)	54 (95%)
	Cognitive speed (logms)		10.57 (0.28)	10.73 (0.33)	0.05	[−0.99, 0.01]
	Accuracy (arc.proportion correct)		3.00 (0.26)	2.88 (0.42)	0.20	[−0.18, 0.83]
	Executive function (error rate)		26.50 (17.87)	19.09 (8.12)	0.02	[0.09, 1.07]
	Composite Z -score		0.16 (2.27)	−0.08 (2.25)	0.68	[−0.90, 1.38]
1H-MRS	Number of participants, n		24	12
	Participants on cART, n(%)		17 (71%)	9 (75%)
	Frontal grey matter	NAA/Cr	1.42 (0.25)	1.35 (0.10)	0.32	[−0.41, 1.21]
		Cho/Cr	0.59 (0.12)	0.63 (0.17)	0.31	[−2.38, 0.77]
		mI/Cr	0.70 (0.28)	0.62 (0.13)	0.39	[−0.10, 0.25]
	Frontal white matter	NAA/Cr	1.53 (0.32)	1.48 (0.26)	0.63	[−0.42, 0.68]
		Cho/Cr	1.04 (0.20)	1.02 (0.19)	0.73	[−0.69, 0.98]
		mI/Cr	0.96 (0.48)	0.83 (0.54)	0.47	[−0.23, 0.49]
	Basal ganglia	NAA/Cr	1.71 (0.25)	1.65 (0.29)	0.54	[−0.45, 0.84]
		Cho/Cr	0.77 (0.12)	0.80 (0.19)	0.36	[−2.27, 0.85]
		mI/Cr	0.71 (0.22)	0.55 (0.23)	0.06	[−0.01, 0.32]
PK11195 BP	Number of participants, n		8	8
	Participants on cART, n(%)		6 (75%)	6 (75%)
	Ventral striatum		0.18 (0.10)	0.22 (0.13)	0.45	[−3.46, 1.64]
	Caudate		0.08 (0.04)	0.09 (0.08)	0.69	[−5.76, 3.94]
	Putamen		0.21 (0.11)	0.28 (0.14)	0.29	[−3.49, 1.14]
	Thalamus		0.52 (0.31)	0.55 (0.17)	0.84	[−1.44, 1.19]
	Parietal		0.07 (0.06)	0.10 (0.06)	0.33	[−7.56, 2.71]
	Temporal		0.13 (0.03)	0.16 (0.05)	0.16	[−10.82, 1.99]
	Occipital		0.13 (0.04)	0.19 (0.09)	0.10	[−6.58, 0.54]
	Frontal		0.83 (0.40)	1.03 (0.27)	0.26	[−1.34, 0.40]

[Legend Table 2: FGM =  frontal grey matter; FWM = frontal white matter; BG = basal ganglia; NAA = N-acetyl aspartate; Cr = creatine; Cho = choline; mi = myo-inositol peak].