Table 3. Results of univariate and multivariate analyses to examine clinical parameters associated with executive function performance, composite speed and basal ganglia mI/Cr ratio.
Cerebral functionassessment result | Poorerexecutivefunction | Poorerexecutivefunction | FasterCompositespeed | FasterCompositespeed | Higher basalgangliamI/Cr ratio | Higher basalgangliamI/Cr ratio |
Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | |
Clinical parameter | p -value [95% CI] | p- value [95% CI] | p -value [95% CI] | p- value [95% CI] | p -value [95% CI] | p- value [95% CI] |
aHCV study group | 0.02 [0.09, 1.07] | 0.001 [5.8, 20.1] | 0.05 [−0.99, 0.00] | 0.22 [−0.3, 0.1] | 0.06 [−0.01, 0.32] | 0.03 [0.02, 0.35] |
Nadir CD4+ count,per 100 cell/uL increase | 0.09 [−0.30, 0.02] | 0.001 [−0.1, −0.02] | 0.03 [−0.33, −0.02] | 0.10 [−0.01, 0.00] | 0.09 [−0.10, 0.01] | 0.05 [−0.11, 0.00] |
Current CD4+ count,per 100 cell/uL increase | 0.70 [−0.12, 0.08] | − | 0.05 [−0.20, −0.00] | 0.78 [−0.05, 0.03] | 0.83 [−0.05, 0.04] | − |
Age, per 10 year increase | 0.68 [−0.28, 0.18] | 0.59 [−3.9, 2.2] | 0.03 [0.02, 0.47] | 0.20 [−0.30, 1.30] | 0.45 [−0.12, 0.06] | − |
Receiving cART | 0.70 [−0.95, 0.65 | 0.37 [−18.8, 7.1] | 0.42 [−0.47, 1.12] | 0.79 [−0.34, 0.26] | 0.58 [−0.14, 0.24] | − |
Plasma VL,per 1000 c/mL increase | 0.37 [−0.38, 0.14] | 0.06 [−0.54, 0.01] | 0.82 [−0.01, 0.01] | 0.59 [−0.01, 0.01] | 0.84 [−0.01, 0.01] | − |
Time since HIV diagnosis,per 10 year increase | 0.34 [−0.06, 0.02] | 0.15 [−0.85, 0.13] | 0.57 [−0.03, 0.05] | 0.54 [−0.02, 0.01] | 0.81 [−1.58, 1.25] | − |