Table 1. HPV statuses and 5-year control and survival rates in advanced OSCC patients (n = 173).
| Characteristics | Local control | P | Neck control | P | Distant metastases | P | Disease-free survival | P | Disease-specificsurvival | P | Overallsurvival | P |
| (n, %) | (5-yr %, n event) | (5-yr %, n event) | (5-yr %, n event) | (5-yr %, n event) | (5-yr %, n event) | (5-yr %, nevent) | ||||||
| Solitary HPV-16 | 0.774 | 0.726 | 0.007 | 0.058 | 0.025 | 0.028 | ||||||
| No (157, 91) | 84 (23) | 82 (28) | 19 (28) | 62 (61) | 68 (50) | 53 (80) | ||||||
| Yes (16, 9) | 87 (2) | 77 (3) | 56 (7) | 38 (9) | 37 (9) | 25 (12) | ||||||
| Solitary HPV-18 | 0.797 | 0.416 | 0.685 | 0.955 | 0.996 | 0.602 | ||||||
| No (161, 93) | 86 (23) | 81 (30) | 20 (32) | 60 (65) | 66 (55) | 46 (87) | ||||||
| Yes (12, 7) | 83 (2) | 92 (1) | 25 (3) | 58 (5) | 67 (4) | 58 (5) | ||||||
| HPV-16 and/or HPV18 | 0.378 | 0.634 | 0.031 | 0.125 | 0.057 | 0.088 | ||||||
| No (143, 83) | 86 (20) | 81 (27) | 18 (25) | 62 (55) | 69 (45) | 49 (73) | ||||||
| Yes (30, 17) | 83 (5) | 87 (4) | 43 (10) | 50 (15) | 53 (14) | 37 (19) | ||||||
| High-risk HPV | 0.361 | 0.653 | 0.147 | 0.188 | 0.078 | 0.073 | ||||||
| No (137, 79) | 86 (19) | 81 (26) | 18 (25) | 61 (53) | 69 (43) | 50 (69) | ||||||
| Yes (36, 21) | 83 (6) | 86 (5) | 28 (10) | 53 (17) | 56 (16) | 36 (23) | ||||||
| HPV | 0.512 | 0.528 | 0.230 | 0.352 | 0.158 | 0.113 | ||||||
| No (135, 78) | 86 (19) | 81 (26) | 19 (25) | 61 (53) | 68 (43) | 50 (68) | ||||||
| Yes (38, 22) | 84 (6) | 87 (5) | 27 (10) | 55 (17) | 58 (16) | 37 (24) |
HPV: human papillomavirus. OSCC: oral squamous cell carcinoma. n: patient number. W-M: Well-moderate.