Table 4. Demographic, clinical, pathological, and therapeutic characteristics of the advanced OSCC patients with solitary HPV-16 infections.
No. | Sex | Age (y) | Oral habit | Site | p-Stage | ECS | Level IV/V metastases | Tumor depth (mm) | Adjuvant therapy | Interval between primary surgery and relapse (mo) | ||||
TR (mo) | NR (mo) | DM (mo) | Salvage | Outcomes (mo) | ||||||||||
1 | m | 58 | a, b, c | buccal | T3N1 | - | - | 1 | RT | DOO, 2 | ||||
2 | m | 58 | a, b, c | gum | T4N2b | + | - | 35 | CCRT | 7 | – | DOD, 7 | ||
3 | m | 51 | b, c | buccal | T4N1 | - | - | 25 | RT | 6 | – | DOD, 8 | ||
4 | m | 25 | a, b, c | gum | T4N2b | + | - | 12 | CCRT | 7 | – | DOD, 8 | ||
5 | m | 47 | a, b, c | tongue | T4N1 | - | - | 13 | RT | 5 | CCRT | DOD, 14 | ||
6 | m | 62 | a, b, c | buccal | T4N0 | - | - | 50 | RT | DOO, 15 | ||||
7 | m | 73 | a, c | tongue | T2N2b | + | - | 6 | CCRT | 7 | 8 | CCRT | DOD,15 | |
8 | m | 69 | b, c | buccal | T2N2b | + | - | 22 | CCRT | 18 | – | DOD, 19 | ||
9 | m | 31 | a, b, c | gum | T2N2b | + | - | 9 | CCRT | 7 | 18 | CCRT | DOD, 24 | |
10 | m | 47 | b, c | buccal | T2N1 | + | - | 14 | CCRT | 15 | 16 | – | DOD, 25 | |
11 | m | 60 | a, b, c | gum | T4N0 | - | - | 13 | RT | 21 | – | DOD, 26 | ||
12 | m | 47 | a, b, c | tongue | T4N0 | - | - | 12 | RT | DOC, 37 | ||||
13 | m | 69 | a, b, c | gum | T4N2c | + | - | 10 | CCRT | NER, 61 | ||||
14 | m | 45 | a, b, c | mouth floor | T2N2b | + | - | 2 | CCRT | NER, 70 | ||||
15 | f | 54 | B | tongue | T2N2b | - | - | 13 | RT | NER, 79 | ||||
16 | m | 47 | a, b, c | tongue | T3N0 | - | - | 24 | RT | NER, 90 |
OSCC, oral squamous cell carcinoma; HPV, human papillomavirus; m, male; f, female; a, alcohol drinking; b, betel nut chewing; c, cigarette smoking; p, pathological; ECS, extracapsular spread; mo: month; TR, tumor recurrence; NR, neck recurrence; DM, distant metastases; RT, radiotherapy; CCRT, concomitant chemoradiation; DOO, died of other reason; DOC, died of other cancer; DOD, died of disease; NER, no evidence of recurrence.