Table 4. Demographic, clinical, pathological, and therapeutic characteristics of the advanced OSCC patients with solitary HPV-16 infections.

No.	Sex	Age (y)	Oral habit	Site	p-Stage	ECS	Level IV/V metastases	Tumor depth (mm)	Adjuvant therapy	Interval between primary surgery and relapse (mo)
										TR (mo)	NR (mo)	DM (mo)	Salvage	Outcomes (mo)
1	m	58	a, b, c	buccal	T3N1	-	-	1	RT					DOO, 2
2	m	58	a, b, c	gum	T4N2b	+	-	35	CCRT			7	–	DOD, 7
3	m	51	b, c	buccal	T4N1	-	-	25	RT	6			–	DOD, 8
4	m	25	a, b, c	gum	T4N2b	+	-	12	CCRT			7	–	DOD, 8
5	m	47	a, b, c	tongue	T4N1	-	-	13	RT	5			CCRT	DOD, 14
6	m	62	a, b, c	buccal	T4N0	-	-	50	RT					DOO, 15
7	m	73	a, c	tongue	T2N2b	+	-	6	CCRT		7	8	CCRT	DOD,15
8	m	69	b, c	buccal	T2N2b	+	-	22	CCRT			18	–	DOD, 19
9	m	31	a, b, c	gum	T2N2b	+	-	9	CCRT		7	18	CCRT	DOD, 24
10	m	47	b, c	buccal	T2N1	+	-	14	CCRT		15	16	–	DOD, 25
11	m	60	a, b, c	gum	T4N0	-	-	13	RT			21	–	DOD, 26
12	m	47	a, b, c	tongue	T4N0	-	-	12	RT					DOC, 37
13	m	69	a, b, c	gum	T4N2c	+	-	10	CCRT					NER, 61
14	m	45	a, b, c	mouth floor	T2N2b	+	-	2	CCRT					NER, 70
15	f	54	B	tongue	T2N2b	-	-	13	RT					NER, 79
16	m	47	a, b, c	tongue	T3N0	-	-	24	RT					NER, 90

OSCC, oral squamous cell carcinoma; HPV, human papillomavirus; m, male; f, female; a, alcohol drinking; b, betel nut chewing; c, cigarette smoking; p, pathological; ECS, extracapsular spread; mo: month; TR, tumor recurrence; NR, neck recurrence; DM, distant metastases; RT, radiotherapy; CCRT, concomitant chemoradiation; DOO, died of other reason; DOC, died of other cancer; DOD, died of disease; NER, no evidence of recurrence.