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. 2012 Jul 15;23(14):2692–2701. doi: 10.1091/mbc.E12-02-0094

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© 2012 Du et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 7: — Models of CO₂ mediated morphogenesis in C. albicans. The unidentified pathway represents the major pathway involved in CO₂-induced responses. The cAMP signaling and the unidentified pathway converge on the key regulator Flo8 in the regulation of white-to-opaque switching, whereas the two pathways converge on the Flo8–Efg1 complex in the regulation of filamentous growth. HSG, hyphal-specific genes; OSG, opaque-specific genes. (A) A model of CO₂-induced filamentation. (B) A model of CO₂-induced white-to-opaque switching. Wor1 contains a conserved potential PKA phosphorylation site and has been proven to function downstream of the cAMP pathway.