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. 2012 Jul 12;7(7):e40705. doi: 10.1371/journal.pone.0040705

Figure 1. The abundance of Alu-derived small RNAs is decreased in Dicer knockdown HepG2.2.15 cells.

Figure 1

(A) Knockdown of Dicer in HepG2.2.15 cells. Top: representative western blot of Dicer performed at 96 h after siRNA transfection, β-actin was used as loading control. Bottom: the relative level of Dicer determined by real-time RT-PCR, data are shown as mean ± SD from three independent experiments. (B) Classification of small RNAs based on UCSC human genome annotations (hg19) in Dicer knockdown (K/D) and the control (Con) cells. (C) Length distribution and (D) First nucleotide bias of Alu-derived small RNAs.