Table 1.
Single nucleotide variants in GSTT1 reported in the literature.
| Identifier | Common name | Phenotype [PMID] | Frequency [PMID] |
|---|---|---|---|
|
| |||
| 5’ FR (-714)C>T | 0.01 T Coriell AA (Moyer et al, 2007)[18056202][27] | ||
| 0.015 T Coriell CA (Moyer et al, 2007)[18056202] | |||
|
| |||
| 5’ FR (-476)G>A | 0.008 A Coriell CA (Moyer et al, 2007)[18056202][27] | ||
|
| |||
| 5’ FR (-295)C>G | 0.01 G Coriell AA (Moyer et al, 2007)[18056202][27] | ||
|
| |||
| 5’ FR (-56)G>C | 0.32 C Coriell AA (Moyer et al, 2007)[18056202][27] | ||
| 0.008 C Coriell MA (Moyer et al, 2007)[18056202] | |||
|
| |||
| rs4630 C>T | 5’ UTR (−182)C>T | CT had lower neurotoxicity with thalidomide in MM [21435719]. Not assoc with survival in head and neck cancer patients treated with paclitaxel [19504558] | 0.03 C (Grau et al) [19504558][36] |
|
| |||
| rs1130990 C>T | Leu5Leu | 0.01 T Coriell AA (Moyer et al, 2007)[18056202][27] | |
| 0.023 T Coriell CA (Moyer et al, 2007)[18056202] | |||
| 0.008 T Coriell MA (Moyer et al, 2007)[18056202] | |||
| 0/100 Coriell HCA (Moyer et al, 2007) [18056202] | |||
|
| |||
| IVS 1 (-178)C>A | 0.01 A Coriell AA (Moyer et al, 2007)[18056202][27] | ||
|
| |||
| IVS 1 (-151)G>A | 0.01 A Coriell AA (Moyer et al, 2007)[18056202][27] | ||
|
| |||
| IVS 1 (-24)C>T | 0.029 T Coriell AA (Moyer et al, 2007)[18056202][27] | ||
|
| |||
| IVS 1 (-14)T>A | 0.008 A Coriell MA (Moyer et al, 2007)[18056202] [27] | ||
|
| |||
| rs2266635 | Ala21Thr | 0/400 (Agundez et al, 2008)[18303971][30] | |
|
| |||
| rs11550606 | Leu30Pro | 0/400 (Agundez et al, 2008)[18303971][30] | |
|
| |||
| Asp43Asn | Decreased protein [18303971] | 0.01 A Coriell AA (Moyer et al, 2007)[18056202] [27] | |
|
| |||
| rs17856199 | Phe45Cys | 0/400 (Agundez et al, 2008)[18303971][30] | |
|
| |||
| Exon 2 (177)C>T | 0.008 T Coriell CA (Moyer et al, 2007)[18056202][27] | ||
|
| |||
| Thr65Met | Decreased protein [18303971] | 0.008 T Coriell MA (Moyer et al, 2007)[18056202][27] | |
| 0/300 Coriell AA, CA, HCA (Moyer et al, 2007)[18056202] | |||
|
| |||
| IVS 2 (-13)C>T | 0.136T Coriell AA (Moyer et al, 2007)[18056202][27] | ||
| 0.008 T Coriell MA (Moyer et al, 2007)[18056202] | |||
|
| |||
| Exon 3(225)G>A | 0.01 A Coriell AA (Moyer et al, 2007)[18056202][27] | ||
| 0.008 A Coriell MA (Moyer et al, 2007)[18056202] | |||
|
| |||
| rs11550605 A>C | GSTT1*B, Thr104Pro | Decreased protein [18303971] | 0.01 (Alexandrie et al, 2002)[12439221][34] |
| 0/400 (Moyer et al, 2007)[18056202] [27] | |||
| 0/147 (Matsuno et al, 2004)[15202795][35] | |||
| 0/317 (Piacentini et al, 2011) [20563854][32] | |||
| 0/400 (Agundez et al, 2008)[18303971][30] | |||
|
| |||
| Exon 4 G>x | Decreased protein [18303971] | 0.008 T Coriell MA (Moyer et al, 2007)[18056202][27] | |
|
| |||
| rs2266633 | Asp141Asn | 0/400 (Agundez et al, 2008)[18303971][30] | |
|
| |||
| rs2266637 G>A | Val169Ile | 0.126 A Coriell AA (Moyer et al, 2007)[18056202][27] | |
| 0.008 A Coriell MA (Moyer et al, 2007)[18056202] | |||
|
| |||
| rs2234953 G>A | Exon 4 Glu173Lys | 0/86 (Piacentini et al, 2011) [20563854][32] | |
| 0/400 (Agundez et al, 2008)[18303971][30] | |||
|
| |||
| IVS 4 (-87) del CCT | 0.029 del Coriell AA (Moyer et al, 2007)[18056202] [27] | ||
|
| |||
| Exon 5 (573) G>A | 0.008 A Coriell MA (Moyer et al, 2007)[18056202] [27] | ||
|
| |||
| rs17850155 G>A | Exon 5 Lys228Lys | 0/86 (Piacentini et al, 2011) [20563854][32] | |
numbering from Moyer et al, 2007)[18056202]
Abbreviations: MM, multiple myeloma; AA, African American; CA, Caucasian; HCA, Han Chinese; MA, Mexican American.