Table 1.
Compounds (R =) | EC50 (μM) | CC50 (μM) | SI |
---|---|---|---|
6 | 1.1 | 350 | 318 |
7 | 6.2 | > 500 | > 81 |
1a | 3.0 | 450 | 150 |
1b | 7.5 | > 500 | > 67 |
1c | 0.6 | > 500 | > 833 |
2a | 0.4 | 480 | 1200 |
2b | 0.3 | > 500 | > 1667 |
2c | 1.5 | 450 | 300 |
2d | 0.4 | > 500 | > 1250 |
2e | 0.5 | 150 | 300 |
2f | 1.8 | 190 | 106 |
2g | 1.2 | > 500 | > 417 |
2h | 3.5 | > 500 | > 143 |
2i | 0.8 | 250 | 312 |
2j | 0.5 | 200 | 400 |
2k | 0.3 | > 500 | > 1667 |
2l | 1.4 | > 500 | > 357 |
3a | 0.9 | > 500 | > 556 |
3b | 0.4 | > 500 | > 1250 |
3c | 0.6 | > 500 | > 833 |
3d | 0.4 | > 500 | > 1250 |
3e | 0.7 | 90 | 129 |
3f | 0.6 | 62 | 103 |
3g | 0.6 | 85 | 142 |
3h | 1.5 | 320 | 213 |
3i | 2.8 | > 500 | > 179 |
3j | 0.5 | > 500 | > 1000 |
3k | 0.3 | > 500 | > 1667 |
3l | 0.5 | > 500 | > 1000 |
3m | 5.0 | > 500 | > 100 |
3n | 1.0 | > 500 | > 500 |
3o | 1.0 | > 500 | > 500 |
3p | 1.5 | > 500 | > 333 |
3q | 1.1 | > 500 | > 455 |
3r | 1.3 | > 500 | > 385 |
3s | 1.0 | > 500 | > 500 |
3t | 1.0 | > 500 | > 500 |
3u | 2.5 | > 500 | > 200 |
3v | 1.5 | > 500 | > 333 |
EC50: 50% effective concentration, measured by virus yield reduction assay; CC50: 50% cytotoxic concentration, measured by MTT assay; SI: selective index, SI = CC50/EC50.