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. Author manuscript; available in PMC: 2013 Jul 12.
Published in final edited form as: J Med Chem. 2012 Jun 29;55(13):6061–6075. doi: 10.1021/jm300171v

Table 2.

Antiviral Profiles of DNJ Derivatives 4–5 & 7 against BVDV Infection in MDBK Cellsa

Compounds EC50 (μM) CC50 (μM) SI
graphic file with name nihms388302t38.jpg 7 3.0 > 500 > 167
graphic file with name nihms388302t39.jpg 4a 0.8 > 500 > 625
graphic file with name nihms388302t40.jpg 4b 1.2 > 500 > 417
graphic file with name nihms388302t41.jpg 4c 0.2 > 500 > 2500
graphic file with name nihms388302t42.jpg 4d 24 420 175
graphic file with name nihms388302t43.jpg 4e 3.5 390 111
graphic file with name nihms388302t44.jpg 4f 5.5 295 54
graphic file with name nihms388302t45.jpg 5a 11 > 500 > 45
graphic file with name nihms388302t46.jpg 5b > 100 > 500 5
graphic file with name nihms388302t47.jpg 5c 2.0 > 500 > 250
graphic file with name nihms388302t48.jpg 5d 0.9 > 500 > 556
graphic file with name nihms388302t49.jpg 5e 47 > 500 > 11
a

EC50: 50% effective concentration, measured by virus yield reduction assay; CC50: 50% cytotoxic concentration, measured by MTT assay; SI: selective index, SI = CC50/EC50.