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. Author manuscript; available in PMC: 2013 Jul 12.
Published in final edited form as: J Med Chem. 2012 Jun 29;55(13):6061–6075. doi: 10.1021/jm300171v

Table 3.

Antiviral Profiles of Selected Compounds against DENV Infection in BHK Cellsa

Compounds EC50 (μM) CC50 (μM) SI
graphic file with name nihms388302t50.jpg 7 6.5 > 500 > 77
graphic file with name nihms388302t51.jpg 1c 0.3 425 1417
graphic file with name nihms388302t52.jpg 2a 1.6 > 500 > 312
graphic file with name nihms388302t53.jpg 2d 0.3 475 1583
graphic file with name nihms388302t54.jpg 2h 0.4 > 500 > 1250
graphic file with name nihms388302t55.jpg 2k 1.4 > 500 > 357
graphic file with name nihms388302t56.jpg 2l 0.5 > 500 > 1000
graphic file with name nihms388302t57.jpg 3a 1.7 > 500 > 294
graphic file with name nihms388302t58.jpg 3b 0.5 450 900
graphic file with name nihms388302t59.jpg 3c 0.6 > 500 > 833
graphic file with name nihms388302t60.jpg 3j 0.4 > 500 > 1250
graphic file with name nihms388302t61.jpg 3k 1.1 > 500 > 455
graphic file with name nihms388302t62.jpg 3l 0.4 > 500 > 1250
graphic file with name nihms388302t63.jpg 3n 1.7 > 500 > 294
graphic file with name nihms388302t64.jpg 3p 0.4 400 1000
graphic file with name nihms388302t65.jpg 3q 1.3 470 362
graphic file with name nihms388302t66.jpg 3r 0.6 > 500 > 833
graphic file with name nihms388302t67.jpg 3s 0.8 > 500 > 625
graphic file with name nihms388302t68.jpg 3t 4.0 > 500 > 125
graphic file with name nihms388302t69.jpg 3v 0.4 > 500 > 1250
graphic file with name nihms388302t70.jpg 4a 3.2 > 500 > 156
graphic file with name nihms388302t71.jpg 4b 0.3 > 500 > 1667
graphic file with name nihms388302t72.jpg 4c 0.5 > 500 > 1000
graphic file with name nihms388302t73.jpg 5c 8.5 > 500 > 59
graphic file with name nihms388302t74.jpg 5d 2.2 > 500 > 227
graphic file with name nihms388302t75.jpg 5e 20 > 500 > 25
a

EC50: 50% effective concentration, measured by virus yield reduction assay; CC50: 50% cytotoxic concentration, measured by MTT assay; SI: selective index, SI = CC50/EC50.