Table S3.
Multivariate analysis of the joint phenotype of low estimated glomerular filtration rate and history of cataract surgery with plasma pentosidine levels analyzed as a continuous variable
| Group 1c | Group 2c | Group 4c | |
|---|---|---|---|
| Low eGFR | No | Yes | Yes |
| History of cataract surgery | Yes | Yes | No |
| RR (95% CI) | RR (95% CI) | RR (95% CI) | |
|
|
|||
| Model 1 (without age in the model)a | |||
| Pentosidine | 1.001 (0.998–1.002) | 1.002 (1.001–1.004) | 1.001 (0.999–1.002) |
| Hypertension | 0.47 (0.14–1.58) | 3.25 (0.58–18.15) | 13.42 (1.63–110.77) |
| Diabetic retinopathy | 2.95 (0.80–10.93) | 7.10 (2.13–23.69) | 3.26 (1.17–9.12) |
| Model 2 (with age in the model)b | |||
| Pentosidine | 1.000 (0.998–1.002) | 1.002 (1.001–1.004) | 1.001 (0.999–1.002) |
| Age | 1.14 (1.06–1.23) | 1.21 (1.12–1.32) | 1.08 (1.03–1.14) |
| Hypertension | 0.28 (0.07–1.05) | 1.38 (0.21–9.6) | 9.94 (1.18–83.49) |
| Diabetic retinopathy | 3.86 (0.96–15.47) | 9.79 (2.53–37.84) | 3.67 (1.23–10.98) |
Notes:
a
apart from pentosidine, only covariates (history of hypertension and diabetic retinopathy) which were statistically significant in the final model are shown;
b
apart from pentosidine, only covariates (history of hypertension and diabetic retinopathy) which were statistically significant in the final model are shown;
c
group 3 is the referent category.
Abbreviations: CI, confidence interval; eGFR, estimated glomerular filtration rate; RR, relative risk.