Table S1.
Multivariate analysis of the joint phenotype of low eGFR and history of cataract with plasma pentosidine levels analyzed as a continuous variable
| Group 1c | Group 2c | Group 4c | |
|---|---|---|---|
| Low eGFR | No | Yes | Yes |
| History of cataract | Yes | Yes | No |
| RR (95% CI) | RR (95% CI) | RR (95% CI) | |
|
|
|||
| Model 1 (without age in the model)a | |||
| Pentosidine | 0.999 (0.998–1.002) | 1.002 (1.001–1.004) | 0.999 (0.998–1.001) |
| HbA1c (%) | 1.52 (0.93–2.48) | 0.70 (0.38–1.29) | 1.26 (0.75–2.12) |
| Hypertension | 1.32 (0.44–3.96) | 9.04 (1.60–50.93) | 12.39 (1.43–107.41) |
| Diabetic retinopathy | 1.78 (0.48–6.64) | 6.89 (1.82–26.04) | 3.59 (0.95–13.55) |
| Model 2 (with age in the model)b | |||
| Pentosidine | 0.999 (0.998–1.001) | 1.002 (1.0002–1.003) | 0.999 (0.998–1.001) |
| Age | 1.12 (1.06–1.20) | 1.25 (1.15–1.36) | 1.09 (1.02–1.16) |
| HbA1c (%) | 1.80 (1.05–3.10) | 0.80 (0.39–1.63) | 1.42 (0.81–2.49) |
| Hypertension | 0.99 (0.31–3.20) | 5.02 (0.79–31.94) | 10.56 (1.19–93.61) |
| Diabetic retinopathy | 2.09 (0.50–8.71) | 8.25 (1.78–38.17) | 4.13 (0.98–17.50) |
Notes:
a
Apart from pentosidine, only covariates (HbA1c, history of hypertension and diabetic retinopathy) which were statistically significant in the final model are shown;
b
apart from pentosidine, only covariates (HbA1c, history of hypertension [P = 0.058], diabetic retinopathy) which were statistically significant in the final model are shown;
c
group 3 is the referent category.
Abbreviations: CI, confidence interval; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c; RR, relative risk.