Table 1.
Distribution of Characteristics of Breast Cancer Patients in Different Response Groups
| |
|
Clin. (breast) |
|
Path. (breast) |
|
Path. (breast+axilla) |
|
Path. (breast+axilla) |
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
|
cOR |
cNR |
|
pOR |
pNR |
|
pOR |
pNR |
|
pCR |
Non-pCR |
|
||||||||
| Characteristics | Total n=54 | n | % | n | % | p | n | % | n | % | p | n | % | n | % | p | n | % | n | % | p |
| Age (years) | 0.340 | 0.091 | 0.054 | 0.068 | |||||||||||||||||
| <50 | 27 | 22 | 81.5 | 5 | 18.5 | 20 | 74.1 | 7 | 25.9 | 19 | 70.4 | 8 | 29.6 | 7 | 25.9 | 20 | 74.1 | ||||
| ≥50 | 27 | 19 | 70.4 | 8 | 29.6 | 14 | 51.9 | 13 | 48.1 | 12 | 44.4 | 15 | 55.6 | 2 | 7.4 | 25 | 92.6 | ||||
| Tumor size (baseline) | 0.949 | 0.432 | 0.653 | 0.512 | |||||||||||||||||
| ≤5cm | 37 | 28 | 75.7 | 9 | 24.3 | 22 | 59.5 | 15 | 40.5 | 22 | 59.5 | 15 | 40.5 | 7 | 18.9 | 30 | 81.1 | ||||
| >5cm | 17 | 13 | 76.5 | 4 | 23.5 | 12 | 70.6 | 5 | 29.4 | 9 | 52.9 | 8 | 47.1 | 2 | 11.8 | 15 | 88.2 | ||||
| ER | 0.401 | 0.017 | 0.059 | 0.083 | |||||||||||||||||
| Negative | 22 | 18 | 81.8 | 4 | 18.2 | 18 | 81.8 | 4 | 18.2 | 16 | 72.7 | 6 | 27.3 | 6 | 27.3 | 16 | 72.7 | ||||
| Positive | 32 | 23 | 71.9 | 9 | 28.1 | 16 | 50.0 | 16 | 50.0 | 15 | 46.9 | 17 | 53.1 | 3 | 9.4 | 29 | 90.6 | ||||
| PgR | 0.198 | 0.325 | 0.456 | 0.903 | |||||||||||||||||
| Negative | 29 | 20 | 69.0 | 9 | 31.0 | 20 | 69.0 | 9 | 31.0 | 18 | 62.1 | 11 | 37.9 | 5 | 17.2 | 24 | 82.8 | ||||
| Positive | 25 | 21 | 84.0 | 4 | 16.0 | 14 | 56.0 | 11 | 44.0 | 13 | 52.0 | 12 | 48.0 | 4 | 16.0 | 21 | 84.0 | ||||
| HER2 | 0.923 | 0.591 | 0.322 | 0.887 | |||||||||||||||||
| Negative | 41 | 31 | 75.6 | 10 | 24.4 | 25 | 61.0 | 16 | 39.0 | 22 | 53.7 | 19 | 46.3 | 7 | 17.1 | 34 | 82.9 | ||||
| Positive | 13 | 10 | 76.9 | 3 | 23.1 | 9 | 69.2 | 4 | 30.8 | 9 | 69.2 | 4 | 30.8 | 2 | 15.4 | 11 | 84.6 | ||||
| IHC-based subtype | 0.778 | 0.048 | 0.062 | 0.404 | |||||||||||||||||
| Luminal-like (HR+) | 33 | 24 | 72.7 | 9 | 27.3 | 17 | 51.5 | 16 | 48.5 | 16 | 48.5 | 17 | 51.5 | 4 | 12.1 | 29 | 87.9 | ||||
| ERBB2+(HR-HER2+) | 6 | 5 | 83.3 | 1 | 16.7 | 6 | 100.0 | 0 | 0.0 | 6 | 100.0 | 0 | 0.0 | 2 | 33.3 | 4 | 66.7 | ||||
| Basal (HR-HER2-) | 15 | 12 | 80.0 | 3 | 20.0 | 11 | 73.3 | 4 | 26.7 | 9 | 60.0 | 6 | 40.0 | 3 | 20.0 | 12 | 80.0 | ||||
| Stathmin expr. | 0.492 | 0.033 | 0.039 | 0.061 | |||||||||||||||||
| First tercile | 18 | 14 | 77.8 | 4 | 22.2 | 13 | 72.2 | 5 | 27.8 | 13 | 72.2 | 5 | 27.8 | 5 | 27.8 | 13 | 72.2 | ||||
| Second tercile | 18 | 15 | 83.3 | 3 | 16.7 | 14 | 77.8 | 4 | 22.2 | 12 | 66.7 | 6 | 33.3 | 4 | 22.2 | 14 | 77.8 | ||||
| Third tercile | 18 | 12 | 66.7 | 6 | 33.3 | 7 | 38.9 | 11 | 61.1 | 6 | 33.3 | 12 | 66.7 | 0 | 0.0 | 18 | 100.0 | ||||
| p53 | 0.100 | 0.018 | 0.030 | 0.438 | |||||||||||||||||
| Negative | 21 | 14 | 66.7 | 7 | 33.3 | 9 | 42.9 | 12 | 57.1 | 8 | 38.1 | 13 | 61.9 | 2 | 9.5 | 19 | 90.5 | ||||
| Positive | 29 | 25 | 86.2 | 4 | 13.8 | 22 | 75.9 | 7 | 24.1 | 20 | 69.0 | 9 | 31.0 | 5 | 17.2 | 24 | 82.8 | ||||
p-value in bold indicates <0.10.
Clin, clinical; Path, pathological; OR, objective response; NR, on response; pCR, pathological complete remission; expr, expression.