Table 2.
Genes for which increased expression was associated with increased recurrence risk
| HUGO Gene Symbol | Rank | Gene Name | EntrezGene ID | Chromosome | Nominal P Value | Kon’rs Adjusted P Value | Hazard Ratio | Correlation with TOP2A |
|---|---|---|---|---|---|---|---|---|
| TOP2A | 1 | Topoisomerase II alpha | 7153 | 17q21-q22 | 5.67E-06 | 0.01 | 1.55 | — |
| DEPDC1 | 2 | DEP domain containing 1 | 55635 | 1p31.2 | 8.39E-06 | 0.01 | 1.67 | 0.7 |
| NUSAP1 | 3 | nucleolar and spindle associated protein 1 | 51203 | 15q15.1 | 9.58E-06 | 0.01 | 1.64 | 0.56 |
| AURKB | 4 | aurora kinase B | 9212 | 17p13.1 | 1.21E-05 | 0.01 | 1.59 | 0.74 |
| KIFC1 | 5 | kinesin family member C1 | 3833 | 6p21.3 | 6.75E-05 | 0.0299 | 1.59 | 0.71 |
| GAPDH | 6 | Glyceraldehyde 3 phosphate dehydrogenase | 2597 | 12p13 | 8.07E-05 | 0.0339 | 2.55 | <0.5 |
| BUB1B | 7 | BUB1 budding uninhibited by benzimidazoles 1 homolog beta | 701 | 15q15.1 | 0.00025 | 0.0399 | 6.69 | 0.65 |
| BIRC5 | 8 | baculoviral IAP repeat-containing 5 (survivin) | 332 | 17q25 | 0.0003 | 0.0339 | 1.4 | 0.8 |
| TYMS | 9 | Thymidylate synthase | 7298 | 18p11.32 | 0.00041 | 0.0439 | 1.59 | 0.71 |
| PLK1 | 10 | polo-like kinase 1 | 5347 | 16p12.1 | 0.00042 | 0.0439 | 1.45 | 0.74 |